Eco-Friendly Solvent-Free Infrared (IR) Spectroscopic Method for Voglibose Determination
| dc.contributor.author | Kritika Verma | |
| dc.contributor.author | Shibam Das | |
| dc.contributor.author | Amit Sharma | |
| dc.contributor.author | Rohit Bhatia | |
| dc.date.accessioned | 2025-12-19T09:35:39Z | |
| dc.date.available | 2025-12-19T09:35:39Z | |
| dc.date.issued | 2024-04-20 | |
| dc.description.abstract | Background: Voglibose, an α-glucosidase inhibitor used in diabetes management, traditionally requires chromatographic or solvent-based methods for quantification. However, IR spectroscopy offers a rapid, non-destructive, and cost-effective alternative without chemical waste. This method enhances sustainability while maintaining accuracy and sensitivity in pharmaceutical analysis. Purpose: To validate a method for quantifying voglibose using Fourier-transform infrared (FTIR) spectroscopy, emphasizing its environmental benefits and applicability in academic and industrial settings. Methods: The FTIR spectroscopy method was developed without the use of organic solvents, requiring only grinding of powders for pellet preparation. Spectra were recorded in absorbance mode within the 868.47–829.40 cm⁻¹ region, based on Beer’s law, to construct a calibration model. Validation was performed according to International Council for Harmonization (ICH) guidelines. Results: The method demonstrated linearity with a regression coefficient of 0.996. It was precise, accurate (average recovery of 98.68%), and robust across a concentration range of 0.5 to 5.0 mg. The method minimizes waste generation, offering an eco-friendly alternative to conventional techniques. Conclusion: The validated FTIR spectroscopy method for voglibose quantification in raw materials is a reliable, accurate, and environmentally sustainable alternative for standard quality control processes in both academic and industrial applications. | |
| dc.identifier.issn | 2321-2217 | |
| dc.identifier.issn | 2321-2225 | |
| dc.identifier.other | https://doi.org/10.15415/jptrm.2024.121007 | |
| dc.identifier.uri | https://demodspace.chitkara.edu.in/handle/123456789/296 | |
| dc.language.iso | en | |
| dc.publisher | Chitkara University Publications | |
| dc.subject | Voglibose | |
| dc.subject | Analytical methods | |
| dc.subject | Quality control | |
| dc.subject | FTIR spectroscopy | |
| dc.subject | Quantitative | |
| dc.subject | Validation | |
| dc.title | Eco-Friendly Solvent-Free Infrared (IR) Spectroscopic Method for Voglibose Determination | |
| dc.type | Article |