Eco-Friendly Solvent-Free Infrared (IR) Spectroscopic Method for Voglibose Determination
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Date
2024-04-20
Journal Title
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Volume Title
Publisher
Chitkara University Publications
Abstract
Background: Voglibose, an α-glucosidase inhibitor used in diabetes management, traditionally requires chromatographic or solvent-based methods for quantification. However, IR spectroscopy offers a rapid, non-destructive, and cost-effective alternative without chemical waste. This method enhances sustainability while maintaining accuracy and sensitivity in pharmaceutical analysis.
Purpose: To validate a method for quantifying voglibose using Fourier-transform infrared (FTIR) spectroscopy, emphasizing its environmental benefits and applicability in academic and industrial settings.
Methods: The FTIR spectroscopy method was developed without the use of organic solvents, requiring only grinding of powders for pellet preparation. Spectra were recorded in absorbance mode within the 868.47–829.40 cm⁻¹ region, based on Beer’s law, to construct a calibration model. Validation was performed according to International Council for Harmonization (ICH) guidelines.
Results: The method demonstrated linearity with a regression coefficient of 0.996. It was precise, accurate (average recovery of 98.68%), and robust across a concentration range of 0.5 to 5.0 mg. The method minimizes waste generation, offering an eco-friendly alternative to conventional techniques.
Conclusion: The validated FTIR spectroscopy method for voglibose quantification in raw materials is a reliable, accurate, and environmentally sustainable alternative for standard quality control processes in both academic and industrial applications.
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Keywords
Voglibose, Analytical methods, Quality control, FTIR spectroscopy, Quantitative, Validation