JPTRM Vol. 12 No. 1 (May 2024)

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Browsing JPTRM Vol. 12 No. 1 (May 2024) by Author "Amit Sharma"

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    Eco-Friendly Solvent-Free Infrared (IR) Spectroscopic Method for Voglibose Determination
    (Chitkara University Publications, 2024-04-20) Kritika Verma; Shibam Das; Amit Sharma; Rohit Bhatia
    Background: Voglibose, an α-glucosidase inhibitor used in diabetes management, traditionally requires chromatographic or solvent-based methods for quantification. However, IR spectroscopy offers a rapid, non-destructive, and cost-effective alternative without chemical waste. This method enhances sustainability while maintaining accuracy and sensitivity in pharmaceutical analysis. Purpose: To validate a method for quantifying voglibose using Fourier-transform infrared (FTIR) spectroscopy, emphasizing its environmental benefits and applicability in academic and industrial settings. Methods: The FTIR spectroscopy method was developed without the use of organic solvents, requiring only grinding of powders for pellet preparation. Spectra were recorded in absorbance mode within the 868.47–829.40 cm⁻¹ region, based on Beer’s law, to construct a calibration model. Validation was performed according to International Council for Harmonization (ICH) guidelines. Results: The method demonstrated linearity with a regression coefficient of 0.996. It was precise, accurate (average recovery of 98.68%), and robust across a concentration range of 0.5 to 5.0 mg. The method minimizes waste generation, offering an eco-friendly alternative to conventional techniques. Conclusion: The validated FTIR spectroscopy method for voglibose quantification in raw materials is a reliable, accurate, and environmentally sustainable alternative for standard quality control processes in both academic and industrial applications.
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    The Impact of Maternal Obesity on the Development and Outcomes of Congenital Masses: A Review
    (Chitkara University Publications, 2024-04-20) Sarita Jangra; Amit Sharma; Thakur Gurjeet Singh; Bhavesh Dharmani; Tanya Sood; Kritika Sharma; Bhupinder Bhyan; Yousef Saeed Alqarni; Fahad Thabet Alsulami
    Background: The global prevalence of obesity has risen sharply, including among pregnant women, contributing to a significant increase in obstetric complications and adverse birth outcomes. One such concern is the development of congenital anomalies, which include cystic, solid, or vascular malformations. These anomalies are influenced by maternal factors such as pre-pregnancy malnutrition, inadequate folic acid intake, iodine deficiency, consanguineous marriages, insufficient immunization, and exposure to teratogens like alcohol. Addressing the high morbidity associated with these abnormalities requires a deep understanding of their anatomical and etiological factors. Purpose: This review aims to examine the impact of maternal obesity on the development and outcomes of congenital masses. It seeks to identify mechanisms underlying these malformations, assess their prevalence, and explore strategies for prevention and management. Method: A comprehensive literature review was conducted, focusing on studies that link maternal obesity with congenital anomalies. Relevant articles were identified from databases such as PubMed, Scopus, and Web of Science using keywords like “maternal obesity,” “congenital masses,” “foetal malformations,” and “pregnancy outcomes.” Results: Maternal obesity was associated with an increased risk of congenital anomalies due to factors such as altered metabolic states, inflammation, and suboptimal nutrient levels. Early diagnosis and intervention were identified as critical for improving outcomes. Conclusion: Maternal obesity significantly impacts the development and outcomes of congenital masses. Effective prevention strategies, such as nutritional counselling, obesity management, and early screening programs, are essential to mitigate these risks and improve maternal and neonatal health outcomes.