Design, Synthesis and Antidiabetic Activity of Novel Sulfamoyl Benzamide Derivatives as Glucokinase Activators

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dc.contributor.authorAjmer Singh Grewal
dc.contributor.authorKapil Sharma
dc.contributor.authorSukhbir Singh
dc.contributor.authorVikramjeet Singh
dc.contributor.authorDeepti Pandita
dc.contributor.authorViney Lather
dc.date.accessioned2025-12-18T05:32:53Z
dc.date.available2025-12-18T05:32:53Z
dc.date.issued2018-11-02
dc.description.abstractThe present work has been planned to design, synthesize and evaluate the antidiabetic potential of a series of sulfamoyl benzamide derivatives as potential glucokinase (GK) activators. A new series of sulfamoyl benzamide derivatives was synthesized starting from 3-nitrobenzoic acid and characterized. In silico docking studies were performed to determine the binding interactions for the best fit conformations in the allosteric site of GK enzyme. Based on the results of in silico studies, the selected molecules were tested for their antidiabetic activity in animal studies (alloxan induced diabetic animal model). Compound 7 exhibited highest antidiabetic activity in animal studies. The results of in vivo antidiabetic activity studies were found to be in parallel to that of docking studies. These newly synthesized sulfamoyl benzamide derivatives thus can be treated as the initial hits for the development of novel, safe, effective and orally bioavailable GK activators as therapeutic agents for the treatment of type 2 diabetes.
dc.identifier.issn2321-2217
dc.identifier.issn2321-2225
dc.identifier.otherhttps://doi.org/10.15415/jptrm.2018.62008
dc.identifier.urihttps://demodspace.chitkara.edu.in/handle/123456789/222
dc.language.isoen
dc.publisherChitkara University Publications
dc.subjectAntidiabetic activity
dc.subjectBenzamides
dc.subjectDiabetes mellitus
dc.subjectGlucokinase
dc.subjectGK activators
dc.subjectMolecular Docking
dc.titleDesign, Synthesis and Antidiabetic Activity of Novel Sulfamoyl Benzamide Derivatives as Glucokinase Activators
dc.typeBook

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JPTRM Vol. 6 No. 2 (November 2018)