Analgesic Activity of some 1-Phenyl-3-aryl-5- (4-(butanoloxy) phenyl) 1H-pyrazoles

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dc.contributor.authorAnju Goyal
dc.contributor.authorSandeep Jain
dc.date.accessioned2025-12-16T08:58:56Z
dc.date.available2025-12-16T08:58:56Z
dc.date.issued2016-11-02
dc.description.abstractA series of analgesic activity of synthesised 1 -Phenyl-3-aryl- 5-(4-(butanoloxy) phenyl) 1H-pyrazoles were synthesized from chalcones and screened for their in vitro analgesic activity. Chalcones i.e.,1-aryl-3- (4-hydroxyphenyl) prop-2-en-1-ones, 1 on reaction with phenyl hydrazine in presence of acetic acid and few drops of hydrochloric acid furnished the corresponding 1-phenyl-3-aryl-5-(4-hydroxyphenyl)-1H-pyrazoles 2 which on further reaction with 4-chloroalkanol yielded the title compounds 3. These compounds were characterized by CHN analyses, IR, mass and 1H NMR spectral data. All the novel synthesised 1-Phenyl-3-aryl-5-(4-(butanoloxy) phenyl) 1H-pyrazoles were evaluated pharmacologically for their analgesic activity and the title synthesised compounds exhibited significant results as compared to standard drug.
dc.identifier.issn2321-2217
dc.identifier.issn2321-2225
dc.identifier.otherhttps://doi.org/10.15415/jptrm.2016.42008
dc.identifier.urihttps://demodspace.chitkara.edu.in/handle/123456789/197
dc.language.isoen
dc.publisherChitkara University Publications
dc.subjectChalcones
dc.subject1H-pyrazoles
dc.subjectanalgesic activity
dc.titleAnalgesic Activity of some 1-Phenyl-3-aryl-5- (4-(butanoloxy) phenyl) 1H-pyrazoles
dc.typeArticle

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JPTRM Vol. 4 No. 2 (November 2016)