Exploring RP-HPLC Method for analysis of Axitinib in Bulk and in-house Tablets

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dc.contributor.authorShailesh S Chalikwar
dc.contributor.authorSatish D Kayande
dc.contributor.authorInderbir Singh
dc.contributor.authorAtul A Shirkhedkar
dc.date.accessioned2025-12-18T05:38:13Z
dc.date.available2025-12-18T05:38:13Z
dc.date.issued2018-11-02
dc.description.abstractAxitinib is a tyrosine kinase Inhibiter. In a commenced analysis, a effortless and responsive high-performance liquid-chromatography method was developed and validated for the quantitative estimation of Axitinib in bulk and in-house tablet dosage form. The present method was developed and validated using LC-GC Qualisil BDS C18 (250 mm × 4.6 mm, 5 μm). The separation of Axitinib was employed using a methanol: water 85:15% v/vas a mobile phase at optimal flow rate 1 mL/min and column oven temperature 30°C. While, Axitinib was examined at 330 nm with a photo diode array detector; retention timewas found to be 3.23 min.The intended method was validated by ICH rules for the accuracy, precision, sensitivity, and ruggedness. The linearity was followed in the concentration range of 4 – 24 μg/ mL as demonstrated by correlation coefficient (r2) of 0.9994. The robustness of proposed method was assessed by purposelyvarying the chromatographic conditions. Consequently, the intended method can routinely be subjected for th estimation of Axitinib in bulk and in tablets formulation.
dc.identifier.issn2321-2217
dc.identifier.issn2321-2225
dc.identifier.otherhttps://doi.org/10.15415/jptrm.2018.62010
dc.identifier.urihttps://demodspace.chitkara.edu.in/handle/123456789/224
dc.language.isoen
dc.publisherChitkara University Publications
dc.subjectAxitinib
dc.subjectHPLC
dc.subjectvalidation
dc.subjectin-house tablets
dc.titleExploring RP-HPLC Method for analysis of Axitinib in Bulk and in-house Tablets
dc.typeArticle

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JPTRM Vol. 6 No. 2 (November 2018)