Evaluation of Ginger Oleoresin in Carbon Tetrachloride Induced Hepatotoxicity in Rats

Simple item page
dc.contributor.authorRavinder Khatri
dc.contributor.authorKashish Bhardwaj
dc.contributor.authorAkshay Sharma
dc.contributor.authorSrijana Tamang
dc.contributor.authorKiran
dc.contributor.authorUmesh Chettri
dc.contributor.authorArvind Sharma
dc.date.accessioned2025-12-18T05:30:47Z
dc.date.available2025-12-18T05:30:47Z
dc.date.issued2018-11-02
dc.description.abstractThe present study evaluated the hepatoprotective activity of ginger oleoresin against Carbontetrachloride induced liver toxic damage in rats. Rats were divided into six groups. Hepatotoxicity was induced by the administration of a single intraperitoneal dose (2ml/kg) of Carbontetrachloride in experimental rats. Post-treatment with Ginger oleoresin at 300 and 600mg/kg dose given by oral routewas carried out to find their protective effectsagainst carbontetrachloride induced hepatic injury. Biochemical parameterfor oxidative stress, inflammation and lipid profile along with genotoxicity and histological changes in rat serum and liver were studied. Silymarin was used as standard hepatoprotective agent. Extracted oleoresin dose dependently provided hepatoprotective effects.The hepatoprotective action of ginger oleoresin may be related to its free radical scavenging,anti-inflammatory and hypolipidemic activity and concluded to be partly mediated by its active constituent’s 6-gingerol, shogaol and zingerone. -phospate; CCl3 *, Trichloromethyl free radical; CCl3 OO*, Trichloromethyl peroxy radical; ROS, Reactive oxygen species; iNOS, inducible nitric oxide synthase; NO, Nitric oxide, VLDL, Very low density lipoprotein.
dc.identifier.issn2321-2217
dc.identifier.issn2321-2225
dc.identifier.otherhttps://doi.org/10.15415/jptrm.2018.62007
dc.identifier.urihttps://demodspace.chitkara.edu.in/handle/123456789/221
dc.language.isoen
dc.publisherChitkara University Publications
dc.subjectGinger oleoresin
dc.subjecthepatotoxicity
dc.titleEvaluation of Ginger Oleoresin in Carbon Tetrachloride Induced Hepatotoxicity in Rats
dc.typeArticle

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
JPTRM Volume 6 Issue 2 001.pdf
Size:
1.07 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed to upon submission
Description:
Download

Collections

JPTRM Vol. 6 No. 2 (November 2018)