In Silico Evaluation of Reserpine as Potential Anti-Candidal Agent

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dc.contributor.authorNidhi Rani
dc.contributor.authorRajwinder Kaur
dc.contributor.authorPrerna Sharma
dc.contributor.authorPraveen Kumar
dc.date.accessioned2025-12-18T10:02:29Z
dc.date.available2025-12-18T10:02:29Z
dc.date.issued2021-05-07
dc.description.abstractBackground: Candida albicans is a fungus that can cause mortality if not treated properly. Lanosterol 14α-demethylase produces Ergosterol, the main sterol in the fungal cell membrane, when the enzyme Lanosterol-demethylase is present (Cytochrome P450DM). This enzyme is a target enzyme for azole antifungal medications. Purpose: In silico evaluation of reserpine as Potential Anti-Candidal agent. Method: The target enzyme was chosen and modelled as part of the project. Molecular docking studies were used to investigate Reserpine’s inhibitory impact on Cytochrome P450. MolegroVirtual Docker was used to conduct molecular docking and Chem sketch was utilised to build compound structures. Result and conclusion: According to the docking research, reserpine exhibited interactions with the demethylase enzyme.
dc.identifier.issn2321-2217
dc.identifier.issn2321-2225
dc.identifier.otherhttps://doi.org/10.15415/jptrm.2021.91001
dc.identifier.urihttps://demodspace.chitkara.edu.in/handle/123456789/248
dc.language.isoen
dc.publisherChitkara University Publications
dc.subjectAntifungals
dc.subjectIndole alkaloids
dc.subjectReserpine
dc.subjectRauwolfiaserpentina
dc.subjectMolecular docking
dc.titleIn Silico Evaluation of Reserpine as Potential Anti-Candidal Agent
dc.typeArticle

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JPTRM Vol. 9 No. 1 (May 2021)