Chemical Induced Rodent Model of Autism Spectrum Disorders

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dc.contributor.authorKavita Chauhan
dc.contributor.authorVeerta Sharma
dc.contributor.authorHeena Khan
dc.contributor.authorAmarjot Kaur
dc.contributor.authorThakur Gurjeet Singh
dc.date.accessioned2025-12-19T07:02:09Z
dc.date.available2025-12-19T07:02:09Z
dc.date.issued2022-11-10
dc.description.abstractThe term Autism spectrum disorder (ASD) refers to a neuro-developmental disorder that include repetitive behaviours, extremely constrained interests and deficits in social communication. In the last ten years, the numerous epidemiological papers discussing connection between autism and environmental chemical exposures has significantly increased. These findings are crucial because they focus on modifiable risk factors that may open up new possibilities for the primary prevention of the autism-related disability, which is now recognised to be more strongly related to environmental factors than was previously thought. A variety of environmental factors have been known as significant factors relevant to aetiology of ASD, such as lead and mercury (heavy metals), PCB(organic contaminant) and phthalates and BPA. The most accurate animal model of autism among all other models is valproic acid-induced autism, which can reproduce almost all of the molecular and cellular changes seen in humans with ASD. This review provide insight into various diagnostic available for autism, pathophysiology of autism and animal model of autism to develop a pharmacological therapeutic intervention for the treatment of disease.
dc.identifier.issn2321-2217
dc.identifier.issn2321-2225
dc.identifier.otherhttps://doi.org/10.15415/jptrm.2022.102003
dc.identifier.urihttps://demodspace.chitkara.edu.in/handle/123456789/269
dc.language.isoen
dc.publisherChitkara University Publications
dc.subjectAnimal models
dc.subjectVPA
dc.subjectBPA
dc.subjectTHIM
dc.subjectAutism
dc.titleChemical Induced Rodent Model of Autism Spectrum Disorders
dc.typeArticle

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JPTRM Vol. 10 No. 2 (November 2022)