A Review on Role of Advanced Glycation End products (AGEs) in Rheumatoid Arthritis
| dc.contributor.author | Ravinder Kumar | |
| dc.contributor.author | Sandeep Arora | |
| dc.contributor.author | Pratima Syal | |
| dc.contributor.author | Mayank Sippy | |
| dc.date.accessioned | 2025-12-16T06:54:14Z | |
| dc.date.available | 2025-12-16T06:54:14Z | |
| dc.date.issued | 2015-05-20 | |
| dc.description.abstract | Rheumatoid arthritis (RAa) is a systemic inflammatory connective tissue disease with polyarthritis as a prominent feature; however, extra-articular symptoms and signs are always present. Aadvanced glycation end products with ability of cross-linking of proteins characteristic fluorescence and reaction with AaGEe-specific receptor RAaGEe (receptor for AaGEes). AaGEes action as well as AaGEe formation is directly related to both to inflammation and oxidative stress. RAaGEe is a 35-kDa polypeptide whose gene is located at the junction of the class II and III HLAla regions on chromosome. ligation of RAaGEe has been shown to activate p21ras and mitogen-activated protein (MAaP) kinase, and stimulate nuclear translocation of the transcription factor NF-κB, thereby, resulting in the transcription of target genes thus may induce chronic cellular activation and tissue damage. | |
| dc.identifier.issn | 2321-2217 | |
| dc.identifier.issn | 2321-2225 | |
| dc.identifier.other | https://doi.org/10.15415/jptrm.2015.31001 | |
| dc.identifier.uri | https://demodspace.chitkara.edu.in/handle/123456789/178 | |
| dc.language.iso | en | |
| dc.publisher | Chitkara University Publications | |
| dc.subject | Advance glycated end products | |
| dc.subject | RAGE | |
| dc.subject | Rheumatoid arthritis | |
| dc.title | A Review on Role of Advanced Glycation End products (AGEs) in Rheumatoid Arthritis | |
| dc.type | Article |