A Precise Review on Tenofovir Disoproxil Fumarate: An Analytical Profile

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dc.contributor.authorVinod A Chaure
dc.contributor.authorSaurabh B Ganorkar
dc.contributor.authorGanesh U Chaturbhuj
dc.contributor.authorSanjay J Surana
dc.contributor.authorAtul A Shirkhedkar
dc.date.accessioned2025-12-18T05:42:26Z
dc.date.available2025-12-18T05:42:26Z
dc.date.issued2018-11-02
dc.description.abstractTenofovir Disoproxil Fumarate (TDF) is antiretroviral medicine used treat AIDS as well as chronic Hepatitis-B. TDF is a prodrug of tenofovir and exists as dominant form due to lesser oral bioavailability of parent drug. TDF is now available in a fixed-dose combination with various antiretrovirals like Cobicistat, Efavirenz, Elvitegravir, Emtricitabine, Lamivudine, Rilpivirine, and Nevirapine. Hence, pharmaceutical analysis of TDF and applicability of different analytical methods have gained crucial importance. The present review article assesses the published analytical methods and a variety of approach for investigation of TDF in bulk drug as well as pharmaceutical formulations including combinations. This detailed review includes examination of around eighty analytical methods published during 2008 to 2016 using various techniques which include HPLC, HPTLC, and UV/ Visible-Spectrophotometry. The review also illustrates the scope and limitations of many published analytical methods for analysis of TDF. Such detailed review will be of great help to the researcher who is working on TDF. Miscellaneous methods of rare but unique pharmaceutical distinction have also been given due consideration. The diagrammatic illustrations provide the statistical overview about the various methods referred for analysis of TDF.
dc.identifier.issn2321-2217
dc.identifier.issn2321-2225
dc.identifier.otherhttps://doi.org/10.15415/jptrm.2018.62012
dc.identifier.urihttps://demodspace.chitkara.edu.in/handle/123456789/226
dc.language.isoen
dc.publisherChitkara University Publications
dc.subjectTenofovir Disoproxil Fumarate
dc.subjectReview Article
dc.subjectValidation
dc.subjectHPLC
dc.subjectHPTLC
dc.titleA Precise Review on Tenofovir Disoproxil Fumarate: An Analytical Profile
dc.typeArticle

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JPTRM Vol. 6 No. 2 (November 2018)