JPTRM Vol. 6 No. 1 (May 2018)
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Item Evaluation of Polyherbal Anticancer Tablets: A Review(Chitkara University Publications, 2018-05-02) Ishan Dubey; Manmeet Singh Saluja; Ritu M Gilhotra; Mahavir ChhajedCancer is a malignant abnormal growth of cells, one of the most dreaded and complex diseases. It concerns with several tempo spatial changes in cell composition, which finally lead to neoplasia. Various types of cancers have been reported. Chemotherapy, radiation, and/or surgery may cure them. Herbal remedies are supposed to be harmless as they cause fewer complications and are less likely to habitual. Antioxidant compositions of therapeutic plants show the anticancer activity and therefore, use of different proportions of the active components to formulate various standardized preparation with single or multiple components for their synergistic effects play a crucial role in curing cancer. Evaluation parameters to assess the in vitro anticancer activity includes Caspase-3, Caspase-9, alamar blue, LDH assay, XTT assay, sulforhodamine-B assay, MTT assay, DNA fragmentation assay, neutral red uptake cytotoxic assay, tryphan blue assay. Evaluation of dried extract or granules includes bulk density, tapped density, Carr’s index, Hausner’s ratio, angle of repose while the tablets evaluated by drug-excipient compatibility study by FT-IR, stability studies, hardness, thickness, weight variation, friability, disintegration time and dissolution test.Item Phytochemical Investigation and Pharmacological Evaluation of Solanum xanthocarpum Endowed with their potential Activity(Chitkara University Publications, 2018-05-02) Mahavir Chhajed; Atika Jain; Sourabh Gupta; Ishan Dubey; A. K. ShrivastavaThe study was done to assess the in-vitro antibacterial potential of various extracts was studied and compared with ciprofloxacin as the standard and shows significant action against E. coli, B. substilis S. aureus, S. pyrogenes, P. aeruginosa, and S. typhi. Anti-fungal potential of the aqueous extract also studied using miconazole as standard and shows significant action against A. niger and C. albicans. Anthelmintic potential of the aqueous and ethanolic extracts was also studied on earthworms, Eudrillus eugeniae using albendazole as standard and shows moderate activity. In the present study in-vitro free radical scavenging activity of whole plant material performed. Various crude extracts of S. xanthocarpum was prepared by successive maceration process using various solvents such as; chloroform, petroleum ether (60-80o), acetone, ethanol and distilled water. Each one extract have been chosen to study the free radical inhibitory activity by DPPH radical scavenging method. The preliminary phytochemical screening of extracts showed that sterols, alkaloids, glycosides, tannins, saponins, phenolic compounds, carbohydrates and proteins were present in the plant. Petroleum ether, chloroform, acetone, ethanol and distilled water extracts showed 52.69, 46.15, 21.08, 52.72 and 44.35 % respectively compared to standard ascorbic acid. Acetone extract showed poor inhibition of DPPH radical compared to standard and other extracts also.Item Traditional and Novel Herbal Drugs Emerging as Potent Novel Combinations for Managing Morbidities by Pharmacological and Mechanistic Studies(Chitkara University Publications, 2018-05-02) Tapan Behl; Chanchal Kumar; Roshan Kumar Singh; Taruna Katyal Arora; Sandeep AroraBackground: Herbal drugs are used in treatment of diseases since decades. Major contributing factor for their use is easy availability, less expensive and more belief of common population because of relatively less side effects compared to allopathic medicines. Medicines of natural origin or functional foods in the prevention of disease are the need of hour. Hence, the present review focused on activity of four drugs viz. Withania somnifera,Allium sativum,Curcuma longa andAzadirachta indica and role in different clinical complications. Methods: A thorough review of all the articles, research as well as reviews available regarding the concerned topic was performed. MEDLINE database was searched and English language articles were preferably selected. Results: Withania somnifera, Allium sativum, Curcuma longa andAzadirachta indicahave shown alleviation in inflammation, diabetes and cancer states. The herbal drugs have shown beneficial effects in the prevention and treatment of these disorders. Conclusion from these facts:Utilizing this concept, it can be assumed that herbal drugs play an intricate role in safeguarding the health of individuals from life-threatening complications. However, validation and reproducibility of results in clinical trails should be there in order to confirm the safety and efficacy of these herbal drugs.Item Protective Role of Herbal Drugs in Diabetic Neuropathy: An Updated Review(Chitkara University Publications, 2018-05-02) Eshita Sharma; Tapan Behl; Monika Sachdeva; Rashita Makkar; Sandeep AroraMedicinal plants play a beneficial role in health care and are commonly used in preventing and testing diseases and specific ailments. The advantage associated with herbals plants are numerous and cannot be ignored as they have less adherence issues and are accepted widely by the population due to greater belief in Ayurveda since ancient times. Neuropathic pain has immersed as a serious threat to patient that occurs by damaging the blood vessels leading to morbidity and mortality. The present review paper aims in providing an account of various herbal plants that could be employed in treatment of neuropathic pain.Item Development and Validation of UV Spectrophotometric Method for Simultaneous Estimation of Quinfamide and Mebendazole in in-house Pharmaceutical Formulation(Chitkara University Publications, 2018-05-02) Ajinkya G. Dhandar; Saurabh B. Ganorkar; Amod S. Patil; Atul A. ShirkhedkarThe present work described the development of two simple, accurate, rapid, cost effective and reproducible UV-Spectrophotometric methods for the simultaneous estimation of Quinfamide and Mebendazole in bulk and in laboratory mixture using 0.01M methanolic HCl as a solvent. The absorption maximum for Quinfamide and Mebendazole were found to be at 260.00 nm and 232.40 nm respectively. Beer’s – lamberts was followed in concentration ranges of 1 – 6 μg/mL for Quinfamide and 2- 12 μg/mL for Mebendazole. The percentage recovery of Quinfamide and mebendazole ranged from 98.48 to 99.08 and 98.83 to 99.62 (Method I); from 98.14 to 98.93 and 99.16 to 99.35 (Method II) for Quinfamide and Mebendazole. The established methods were sensible for simultaneous quantitative determination of both these drugs in fixed dose combinations. Validation of both these methods was performed as per ICH guidelines. The developed methods can routinely be used for estimation of both these drugs in their combined dosage form.Item Neuropharmacological Profile of Fractions of Actaea acuminata H. Hara Roots(Chitkara University Publications, 2018-05-02) Deepak Kumar; Suresh KumarThe methanol extract of Actaea acuminata roots have beenpreviously reported to exhibit significant antianxiety, anticonvulsant andantidepressant activities. In present study fractionation of crude bioactivemethanol extract was carried out using different solvents employing standardprocedure. Various fractions were evaluated for antianxiety, anticonvulsantand antidepressant activities using elevated plus maze model (EPM), maximalelectroshock-induced convulsions model (MES) and forced / despair swim test(FST) respectively. Successive partitioning of bioactive methanol extract wasdone with ethyl acetate and 1-butanol. The ethyl acetate fraction (EAF; 100mg/kg), 1-butanol fraction (BF; 25 mg/kg) and remaining methanol extract(RME; 70 mg/kg) were subjected to neuropharmacological activities. TheEAF significantly enhanced entries and average time spent in open arms;significantly decreased duration of MES-induced tonic extension phase andsignificantly decreased duration of immobility time of rats in comparisonto control. BF and RME did not exhibit any neuropharmacological activity.Qualitative chemical tests confirmed presence of alkaloids and polyphenolsin EAF. It is finally concluded that alkaloids and/or polyphenols are bioactiveconstituents of A. acuminata which are responsible for neuropharmacologicalactivities.