Journal of Pharmaceutical Technology, Research and Management

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The Journal of Pharmaceutical Technology, Research and Management (JPTRM) is a multidisciplinary, open access journal published as part of the Chitkara University Publications journal series. The journal is dedicated to fostering innovation, collaboration, and knowledge exchange within the global pharmaceutical sciences community. JPTRM aims to provide a streamlined submission and peer review process, ensuring timely publication and a high level of author support at every stage. The journal welcomes high-quality, original research, reviews, and case studies from all areas relevant to pharmaceutical science, technology, and management. Key areas of focus include, but are not limited to: Pharmaceutical formulation and drug delivery systems Biotechnology and nanotechnology applications in pharmacy Quality control, validation, and regulatory sciences Pharmaceutical manufacturing and industrial processes Supply chain management and pharmaceutical operations Pharmacoeconomics and strategic management in healthcare Digital health, automation, and AI in pharmaceutical development Policy, ethics, and global trends impacting the pharmaceutical industry The journal serves as a platform for researchers, industry professionals, and policy-makers to contribute to the advancement of pharmaceutical knowledge in sustainable practices. Submissions that demonstrate interdisciplinary approaches or have practical implications for pharmaceutical innovation and management are especially encouraged. All papers are evaluated on the basis of scientific content. Submissions are first screened for research and publication ethics prior to peer review. The journal reviews each submission from a sound science perspective.

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Now showing 1 - 20 of 154

A Coherent Analytical Review of Indapamide
(Chitkara University Publications, 2022-05-07) A.P. Rajput; A.P. Edlabadkar
Background: Indapamide is a diuretic of particular importance in an antihypertensive therapeutic regime that is profoundly applied to treat hypertension. Besides using as an individual drug for its diuretic and thereby antihypertensive effect, the drug is also a part of crucial combinations with Angiotensin-Converting Enzyme inhibitors. The recent combinations of Indapamide with Perindopril and Delapril work as the best therapies for heart patients. Purpose: Considering the therapeutic and pharmaceutical importance of the drug molecule and its potential to be explored in future drug discovery and delivery, we made efforts to portray the pharmaceutical analytical profile of the drug molecule at ease. Method: The present article is a composition entailing the comparative and critical evaluation of the various analytical approaches explored for the pharmaceutical estimation ofIndapamide as a particular drug in combinations and pharmaceutical as well as biological matrices. The analyses are reviewed for the specificapplications of analytical methods tested Indapamide alone or with other medications. Result: The anticipated study revealed the comparative usage of different research techniques for Indapamide estimation. The study influences the possibility of constraints and focuses on the recent trend in Indapamide analysis. The article also provides an understanding of sample processing, drug extraction method, validation protocols/approaches, and stability studies, including but not limited to the bioanalytical perspectives. Conclusion: This review can be explored thoroughly for the future analytical and pharmaceutical insights of Indapamide to the fullest.
A Comprehensive Review on Therapeutic Potential of Benzimidazole: A Miracle Scaffold
(Chitkara University Publications, 2020-05-20) Ritchu Babbar; Swikriti; Sandeep Arora
Background: Benzimidazole is a category of heterocyclic aromatic compounds formed from the fusion of six membered benzene with five membered imidazolering. The moiety possesses diverse biological and clinical applications. A number of studies have shown that a varied substituent around the benzimidazole nucleus results in pharmacologically active compounds of therapeutic interest. Purpose: Owing to its number of pharmacological properties, this moiety is of choice of interest in designing and synthesis of new therapeutic compounds. The existence of the benzimidazole core in numerous groups of biological agents like antimicrobial, antiviral, antiparasitic, antihypertensive, anticancer, CNS stimulant as well as depressants has made important scaffold for development of many newer therapeutic agents. There is utmost need to understand the synthesis and associated role of benzimidazole derived compounds in different diseases. Therefore, in the present review, we attempt to discuss various derivatives of benzimidazole nucleus with different pharmacological activities. Conclusion: Benzimidazoles have played a great role in discovery of drug and development. Huge attempt has been made towards benzimidazole heterocyclic-based organic compounds with great excellence that resulted in drugs with enormous biological activity. Therapeutic drugs containing benzimidazole nucleus are used in building drugs that serve to be an active area of research. This article becomes a source that will lead to discovery of new opportunities for all researchers interested in benzimidazole-based heterocyclic medicinal chemistry.
A Precise Review on Tenofovir Disoproxil Fumarate: An Analytical Profile
(Chitkara University Publications, 2018-11-02) Vinod A Chaure; Saurabh B Ganorkar; Ganesh U Chaturbhuj; Sanjay J Surana; Atul A Shirkhedkar
Tenofovir Disoproxil Fumarate (TDF) is antiretroviral medicine used treat AIDS as well as chronic Hepatitis-B. TDF is a prodrug of tenofovir and exists as dominant form due to lesser oral bioavailability of parent drug. TDF is now available in a fixed-dose combination with various antiretrovirals like Cobicistat, Efavirenz, Elvitegravir, Emtricitabine, Lamivudine, Rilpivirine, and Nevirapine. Hence, pharmaceutical analysis of TDF and applicability of different analytical methods have gained crucial importance. The present review article assesses the published analytical methods and a variety of approach for investigation of TDF in bulk drug as well as pharmaceutical formulations including combinations. This detailed review includes examination of around eighty analytical methods published during 2008 to 2016 using various techniques which include HPLC, HPTLC, and UV/ Visible-Spectrophotometry. The review also illustrates the scope and limitations of many published analytical methods for analysis of TDF. Such detailed review will be of great help to the researcher who is working on TDF. Miscellaneous methods of rare but unique pharmaceutical distinction have also been given due consideration. The diagrammatic illustrations provide the statistical overview about the various methods referred for analysis of TDF.
A Review on Medication Errors
(Chitkara University Publications, 2015-11-17) Madhaw Dwivedi; Amit Sharma; Sandeep Arora
Role of clinical pharmacist is to provide optimal pharmaceutical care for individual patients and optimal pharmaceutical care is attained when the right drug in the correct dosage and quality reaches the right patients at the right point in time with the right information. Any preventable event that may cause or lead to inappropriate medication use or patient harm during medication to user is called medicational error and is in the control of the health care professional, patient and consumer. In this review on medication errors, prescr-ibing errors (67 %), administration errors (25%), dispensing errors (08%) were found on the basis of review of literature.Prescribing errors are the prime cause of MEs that further leads to subsequent dispensing and administration errors. Medication errors are common cause of adverse drug events or subtherapeutic outcomes of pharmaceutical care.
A Review on Role of Advanced Glycation End products (AGEs) in Rheumatoid Arthritis
(Chitkara University Publications, 2015-05-20) Ravinder Kumar; Sandeep Arora; Pratima Syal; Mayank Sippy
Rheumatoid arthritis (RAa) is a systemic inflammatory connective tissue disease with polyarthritis as a prominent feature; however, extra-articular symptoms and signs are always present. Aadvanced glycation end products with ability of cross-linking of proteins characteristic fluorescence and reaction with AaGEe-specific receptor RAaGEe (receptor for AaGEes). AaGEes action as well as AaGEe formation is directly related to both to inflammation and oxidative stress. RAaGEe is a 35-kDa polypeptide whose gene is located at the junction of the class II and III HLAla regions on chromosome. ligation of RAaGEe has been shown to activate p21ras and mitogen-activated protein (MAaP) kinase, and stimulate nuclear translocation of the transcription factor NF-κB, thereby, resulting in the transcription of target genes thus may induce chronic cellular activation and tissue damage.
A Review on the Role of Coconut Oil in Dermatitis Diseases
(Chitkara University Publications, 2020-11-17) Pavas Sharma; Durga Chauhan; Sujit Bose; Rakesh Kumar; Rajesh Kumar; Amit Mittal
Background: Coconut oil, or copra oil is obtained from the nut/kernel of matured coconuts garnered from the Cocosnucifera. Coconut oil is an edible oil derived from the kernels of harvested mature coconuts harvested from the coconut palm. In recent decades, this oil has risen to the status of a health food superstar in the health food industry. Celebrities are welcoming its use, nutritionists are promoting it, and patients are praising it for its many benefits. Purpose: This oil has been linked to a range of health advantages. These include improvements in skin care, hair care, stress management, losing weight & cholesterol level management, immune modulatory effects, cardiovascular applications, and, most recently, Alzheimer’s disease. However, for several years, coconut oil was demonised, and consumers were led to believe that it was harmful to their health because it would clog arteries and cause heart disease. The tide has shifted, and in recent years, increased awareness of the favourable health advantages of coconut oil has emerged. Conclusion: The usage of coconut oil, particularly crude coconut oil, is increasingly popular; however some individuals are still doubtful. This present review makes an attempt to provide a scientific assessment of the medicinal qualities of this oil.
A Study of Prescribing Habits of Low Molecular Weight Heparin in Cardiovascular Disease in Tertiary Care Hospital
(Chitkara University Publications, 2017-05-05) Madhaw Dwivedi; S. M. Biradar; Ajay Pandey; Anand P. Ambali; Rishu Sharma
Background and Objective: Cardiovascular Diseases (CVDs) are the leading non-communicable diseases and also leading cause of morbidity and mortality worldwide. Low Molecular Weight Heparin (LMWHs) is frequently prescribed medication in CVDs. Prescribing pattern of LMWHs in CVDs is necessary to recommends modifications to achieve rational and cost-effective medical care. Methodology: An inpatients hospital based observational prospective study for a period of six months was carried out. Data was collected from patient medication sheet and analyzed by suitable methods and standard references. Results and Discussion: In our study, a total of 120 patients were enrolled out of 120 patients 84 were male and 36 were female. Antiplatelet drug is maximum prescribing drug in 98 (81.34%) patients out of 120, then after hypolipidaemic drugs in 94 (78.02%), Anticoagulant in 92 (76.36%), Antibiotics in 90 (74.70%), Antianginal in 69 (57.27), Antihypertensive in 64 (53.12%), Diuretics in 59 (48.97%). LMWHs are prescribed in 78 (65%) in which Enoxaparin is prescribed in 67(55%) and Dalteparin in 11(10%) patients out of 120 patients. Total 259 Drug-Drug Interactions (DDI) were found in which 67 were Major, 140 were Moderate, and 52 were Minor. Conclusion: The study show LMWHs are highly prescribed category of anticoagulant. Enoxaparin is prescribed morethan Dalteparin. Antiplatelet drugs are prescribed to every patient who is prescribed with LMWHs to prevent embolic event. Chance of DDI is increases with these combinations. LMWHs and Fibrinolytic drugs are very costly and impart maximum economic burden to middle class family.
A Study of Prescription Practice for Drugs in Rural Area of Dehradun, Uttarakhand, Using WHO Indicators
(Chitkara University Publications, 2019-05-10) Nautiyal Himani; Bani Pankaj; Prajapati Himani; Shakir Saleem
Background It has been seen in recent decades that there is a lot of development in the field of medicine all over the world. This leads to flooding of medicines in the market. Developing countries are also not behind in this regard but there is lack of standards at all levels for medical treatment. The health care delivery system should be improved to secure the quality of life. In the case of Indian markets, it is also consumed with more than 70,000 formulations, compared to approximately 350 formulations listed in the World Health Organization (WHO) Essential Drug List. Several studies conducted in different regions of India have reported that most prescriptions in India are of drugs with “unclear efficiency.” Developing countries need to promote rational drug use which can be achieved by assessing the drug use patterns with the WHO drug use indicators Objective The present study was conducted in a rural area of Dehradun to assess the medicine prescriptions patterns among health facilities in this area using WHO Medication Use indicators. Material and Method: In this study, one hundred patients were interviewed about their socioeconomic statues along with complete medication history and ongoing medications, in a prescribed format. WHO guidelines were used for analyzing the data using Microsoft excel. The study was conducted in danda lakhond a rural area of Dehradun, Uttarakhand. Result We encountered various astonishing results in this study. The gender ratio for the present study was (78:22) for male: female subjects. Socioeconomic status of the study population was significantly good concerning literacy as only 03% of people were illiterate. Total prescribed drug products were 152; this indicates that an average number of drugs per prescription was 1.52. The generic drugs prescribed in this study were 113 which are 74% of the total number of drugs prescribed. When compared with (National List of essential medicines) of India nearly all prescribed drugs (n=152, 98 %) were included in the list. The present study included 10 therapeutic categories of the Prescribed drug, most prescribed drugs (n=34, 34%) were antibiotics in the study area and least prescribed drugs were antiviral drugs i.e. Only (n=03, 3%). Discussion The present study was an attempt to identify the prescribing pattern of drugs in a rural area of Dehradun Uttarakhand. A small study population was interviewed for this assessment. We concluded that prescription practices were good and WHO standards were followed in prescribing the medicines. Although, some parameters should also be corrected for WHO guidelines such as usage of antibiotics in prescriptions practices, average medicines prescribed per patient, and information regarding dosage form prescribed to patients.
A Validated High Performance Thin Layer Chromatographic Method for Simultaneous Estimation of Berberine Chloride and Guggulsterone Z in Herbal Formulation
(Chitkara University Publications, 2019-05-10) Vijaykumar K. Parmar; Deepika Mohanta; Harsh Shah
A simple, precise, and robust high-performance thin layer chromatography (HPTLC) method was developed and validated for the determination of berberine chloride and guggulsterone Z in herbal formulation. Chromatographic separation was achieved on aluminium plates precoated with silica gel G60F254 as the stationary phase and toluene-acetonitrile-formic acid (5:3:0.5 v/v/v) as the mobile phase. Densitometric evaluation was carried out at 264 nm. The present method was validated according to ICH guidelines. The Rf value of berberine chloride and guggulsterone Z was found to be 0.40 ± 0.02 and 0.68 ± 0.02, respectively. The response in terms of peak area was found to be linear over the concentration range of 100-500 ng/spot for berberine chloride and 200-1000 ng/spot for guggulsterone Z with regression coefficient value greater than 0.995 for both the phytoconstituents. The method was validated by determining its accuracy, precision, robustness, specificity and system suitability. The method was found to be accurate, precise and robust to carry out the simultaneous estimation of berberine chloride and guggulsterone Z. The developed method was successfully applied for the simultaneous estimation of berberine chloride and guggulsterone Z in herbal formulation.
Acupuncture: A Potential Therapy for Neurological and Psychiatric Disorders
(Chitkara University Publications, 2023-11-10) Deepak Kajla; Maneesh Mohan; Kenneth C. Ugoeze
Background: Acupuncture, a practice rooted in traditional Chinese medicine for thousands of years, is increasingly recognized as a complementary therapy for neurological and psychiatric disorders. Purpose: This review aims to explore recent advancements in acupuncture’s application for treating specific neurological and psychiatric conditions and to highlight its therapeutic potential and underlying mechanisms. Methods: The review synthesizes findings from extensive research and scientific studies, incorporating insights from modern neuroimaging techniques like functional magnetic resonance imaging (fMRI) and positron emission tomography (PET). It also examines the efficacy of combined modalities, such as laser and electroacupuncture. Results: Acupuncture has demonstrated efficacy in managing neurological conditions such as stroke, neuropathic pain, and neurodegenerative diseases by enhancing cerebral blood flow, promoting neuroplasticity, and providing neuroprotection. Its application in psychiatric disorders, including anxiety, depression, and post-traumatic stress disorder (PTSD), has shown promising outcomes. These therapeutic effects are mediated through mechanisms involving the autonomic nervous system, decreased inflammation, and neurotransmitter regulation. Combining acupuncture with modalities like laser and electroacupuncture has expanded treatment options and enhanced efficacy. Conclusion: Recent advancements underscore acupuncture’s promise as an effective adjuvant therapy for neurological and psychiatric conditions. However, challenges remain in standardizing procedures and refining study designs to better define specific mechanisms and optimize therapeutic parameters. Continued research is essential to establish acupuncture as a reliable treatment option for improving patient outcomes.
Advances in Magnetofection & − Magnetically Guided Nucleic Acid Delievery:a Review
(Chitkara University Publications, 2013-05) Sandeep Arora; Girish Gupta; Sukhbir Singh; Neelam Singh
The aim of this work was to investigate the effects of the nature and concentration of cellulose derivatives on the release kinetics of ibuprofen from hydrogel matrices using a response surface method (RSM). A series of cellulose derivatives, as methyl, hydroxyethyl, hydroxypropyl and hydroxypropyl methyl celluloses (MC, HEC, HPC and HPMC) were used as polymer platforms and their impacts on drug release were studied and compared to those obtained with a reference formulation prepared with HEC. It was shown that the use of HPMC in the gel formulation contributes to the improvement of drug release and consequently its biodisponibility. Indeed, the increase in HPMC concentration forms a controlled system release because polymer chains relaxation. The drug is released under the effects of two phenomena: diffusion and relaxation of polymeric chains. Thus, the kinetic release passes from the kinetics of case II towards Fickian diffusion.
Allium Sativum-Boon to the Herbal World
(Chitkara University Publications, 2024-04-20) Sanchit Dhankhar; Himanshu Sharma; Samrat Chauhan; Pooja Mittal; Vishnu Mittal
Background: For many years, people have utilized Allium Sativum as a spice, culinary addition, and natural cure for several common illnesses, such as earaches, burns, wounds, baldness, migraines, chest colds, dog bites, and insect stings. It is believed that minerals, protein, fixed oil, thiamine, ascorbic acid, and allin are responsible for the therapeutic benefits of Allium Sativum. Purpose: This review covers the pharmacology, pharmacognosy, pharma chemistry, and other therapeutic aspects of this plant. Aside from its antibacterial, antioxidant, and anticancer qualities, allicin is a helpful treatment for cardiovascular disorders. To lessen reactive oxygen species (ROS), the antioxidant allicin inhibits the enzymes that oxidise NADPH. By engaging with various peroxidases, it can also directly lower the concentrations of various ROS within cells. As an inhibitor of cholinesterase, butyrylcholinesterase (BuChE), and autism spectrum disorder (ASD), it treats these disorders. Furthermore, it aids in the preservation of neurotransmitter balance in individuals with ADHD and attention deficit hyperactivity disorder. Methods: Recent literature has been surveyed from PUBMED, Google Scholar, etc. like search engines, for summarizing detailed on-going on the phytochemical properties, biological activities, marketed formulations, patents and therapeutic potential of Allium Sativum (garlic). The search strategy included keywords such as “Allium Sativum,” “allicin,” “garlic therapeutic properties,” “neuroinflammation,” “antioxidant activity,” “phytochemicals,” “marketed formulations, ” “patents, ” and “drug delivery systems.” Results: Allium Sativum offers broad therapeutic benefits, including antibacterial, antioxidant, and cardiovascular protection, making it a valuable natural remedy for various health conditions. Conclusion: Allicin therapy can lessen the effects of metal-induced neurotoxicity in addition to enhancing cognitive function in neurologically ill individuals. Moreover, it may pass across cell membranes with ease. This molecule can oxidise the links that keep cysteine residues in proteins together and the thiol groups in glutathione. It is physiologically active. Aside from its antibacterial, antioxidant, and anticancer qualities, allicin is a helpful treatment for cardiovascular disorders. To lessen reactive oxygen species (ROS), the antioxidant allicin inhibits the enzymes that oxidize NADPH. By engaging with various peroxidases, it can also directly lower the concentrations of various ROS within cells. As an inhibitor of cholinesterase, butyrylcholinesterase (BuChE), and autism spectrum disorder (ASD), it treats these disorders.
Ameliorative Potential of Aminophylline In Restrain Stress Induced Behavioural and Biochemical Alterations
(Chitkara University Publications, 2017-11-02) Rajneet Kaur; Manjinder Kaur; Poonam Arora
This study is designed to investigate the attenuating prospective of aminophylline in immobilization stress generated behavioural changes in rats. Animals were exposed to restrain stress before being subjected to varying doses of aminophylline (1mg/kg, 2mg/kg and 4mg/kg). Behavioural changes were analyzed to assess the intensity and the degree of the stress, by estimating the changes in the exploratory behaviour, spontaneous activity and social behaviour using various paradigms. As a consequence of stress, the behavioral patterns so changed were assessed in the terms of changes in the locomotor activity, number of head dips and increased avoidance behaviour. Aminophylline (4mg/kg) modulated the stress produced changes in the behaviour and oxidative stress generated biochemical alterations in a significant manner (p<0.001). The results so obtained suggest that upon exposure to stress, animal behavioural patterns, biochemical markers levels changed and these changes wereefficiently modulated by aminophylline at therapeutic doses.
An Ethanol-Based Proliposome Technology for Enhanced Delivery and Improved “Respirability” of Antiasthma Aerosols Generated Using a Micropump Vibrating-Mesh Nebulizer
(Chitkara University Publications, 2013-11) Abdelbary M.A. Elhissi; Jasmeet Brar; Mohammad Najlah; Simon A. Roberts; Ahmed Faheem; Kevin M.G. Taylor
Salbutamol sulphate liposomes were generated using ethanolbased proliposomes followed by nebulization using an Aeroneb Pro vibrating-mesh nebulizer. The droplet size, output and fine particle fraction (FPF) of the drug incorporated in liposome formulation were compared to those of a conventional drug solution. Aerosol output was determined gravimetrically and drug output was analyzed by using high performance liquid chromatography. The potential of aerosol deposition in deep lung was evaluated using inertial impaction and laser diffraction. The effect of formulation surface tension on the aerosol performance was studied. Output and FPF were improved using liposomes compared to the conventional solution, for instance, FPF values were 57.85% and 45.81% respectively. The volume median diameter as measured by laser diffraction was respectively 3.44 Î¼m and 3.22 Î¼m; however, the higher FPF of the liposome formulation is justified by the lower polydispersity of its aerosol. The improved aerosol performance using liposomes was attributed to the reduction of surface tension caused by the presence of phospholipid. This is the first study that demons trates the ability of liposomes to improve the nebulized drug output and FPF.
An Insight on Analytical Profile on Bisoprolol Fumarate – A Selective Beta-1 Adrenoreceptor Blocker
(Chitkara University Publications, 2017-11-02) Ajinkya G. Dhandar; Suraj R. Chaudhari; Saurabh B. Ganorkar; Amod S. Patil; Sanjay J. Surana; Atul A. Shirkhedkar
BF is Beta-adreno receptor antagonist and used as an AntiHypertensive Drug. BF gives the blocking action on β1-adrenergic receptors in the heart and vascular smooth muscle. The present review compiles the various approaches implemented for quantification of BF in bulk drug, pharmaceutical matrix and biological fluid. This review represents more than 50 analytical methods which include capillary electrophoresis, HPLC, HPTLC, UV-Spectroscopy, UPLC, impurity profiling and electrochemical methods implemented for estimation of BF as a single component as well as in multicomponent.
An Update on Some Recent Solubility Enhancers as Pharmaceutical Excipients
(Chitkara University Publications, 2016-05-07) Vivek Puri; Pratima Sharma; Manju Nagpal
At present the pharmaceutical academia and industries are focusing on the use of natural materials and resources for development of pharmaceutical product. Due to advances in drug delivery technology, currently, excipients are included in novel dosage forms to fulfill specific functions. Various natural polymers are widely being studied as a potential carrier material for site specific drug delivery because of its non-toxic and biocompatible in nature. Natural polymers (polysaccharides) have been investigated for drug delivery applications as well as in biomedical fields. Modified polymer or synthetic polymers have found its application as a support material for cell culture, tissue engineering and gene delivery. Recent trends towards use of natural products or plant based products demand the replacement of synthetic additives with natural ones. These natural materials have many advantages over synthetic ones as they are biodegradable, chemically inert, less expensive, nontoxic and widely available. This review provides an overview of the different modified polymer derivatives and their applications with special consideration being put on biomedical engineering and controlled drug delivery.
Analgesic Activity of some 1-Phenyl-3-aryl-5- (4-(butanoloxy) phenyl) 1H-pyrazoles
(Chitkara University Publications, 2016-11-02) Anju Goyal; Sandeep Jain
A series of analgesic activity of synthesised 1 -Phenyl-3-aryl- 5-(4-(butanoloxy) phenyl) 1H-pyrazoles were synthesized from chalcones and screened for their in vitro analgesic activity. Chalcones i.e.,1-aryl-3- (4-hydroxyphenyl) prop-2-en-1-ones, 1 on reaction with phenyl hydrazine in presence of acetic acid and few drops of hydrochloric acid furnished the corresponding 1-phenyl-3-aryl-5-(4-hydroxyphenyl)-1H-pyrazoles 2 which on further reaction with 4-chloroalkanol yielded the title compounds 3. These compounds were characterized by CHN analyses, IR, mass and 1H NMR spectral data. All the novel synthesised 1-Phenyl-3-aryl-5-(4-(butanoloxy) phenyl) 1H-pyrazoles were evaluated pharmacologically for their analgesic activity and the title synthesised compounds exhibited significant results as compared to standard drug.
Analytical Method Development and Validation for Assay of Rufinamide Drug
(Chitkara University Publications, 2013-11) Jitender Singh; Sonia Sangwan; Parul Grover; Lovekesh Mehta; Deepika Kiran; Anju Goyal
A simple, rapid, sensitive, cost effective, and reproducible reverse phase high performance liquid chromatographic (RP-HPLC) method was developed and validated for the stability testing of rufinamide. The proposed RP-HPLC method was developed on phenome-nex LunaR C-18 5Î¼m,250 mm Ã— 4.6 mm id. Column (at ambient temperature) and a mobile phase consisting of phosphate buffer: acetonitrile (60:40) was delivered at a flow rate of 1.0ml/ min. The analyte was detected by using a UV detector at the wavelength of 293 nm. The method was found to be linear over the concentration range of 50- 150 Î¼gml-1 (r2=0.999). 30. The retention time of rufinamide was 4.717 min.
Analytical Review on Raloxifene -An Estrogen Receptor Modulator in Different Pharmaceutical Formulations and Biological Fluids
(Chitkara University Publications, 2017-05-05) Ashwini v. Gujar; Anand B. Mundada; Atul A. Shirkhedkar
Raloxifene (RLX) is an oral selective estrogen receptor modulator (SERM). It is showing estrogenic action on bone and anti-estrogenic action on uterus and breast. An extensive literature has been published for analysis of RLX in different pharmaceutical formulations. This review article endeavor to provide the detail account on analytical methods for RLX and also validation details for its readers. It further helps to avoid costly chemicals and time consuming exercises for further investigation of RLX.
Annona Muricata: Unveiling its Potential as a Complementary and Alternative Cancer Therapy
(Chitkara University Publications, 2023-11-10) Shinam Bakshi; Abhinav Yadav; Sanchit Dhankhar; Samrat Chauhan; Shushank Mahajan; Deepak Singla
Background: Soursop (Annona muricata) is a tropical fruit that has recently been under scrutiny for its supposedly appreciable health benefits. The plant is rich in phytochemicals and the medicinal value of the fruit has been under study in treating cancer, diabetes, oxidative stress, hypertension, haemorrhagic disease, and reduction of bad cholesterol. Purpose: The review serves to discuss the potential use of the Annona muricata in nutraceutical and pharmaceutical development. The discussion below is based on the use of soursop pulp, seeds, and leaf extracts as functional ingredients in food products and their implications for pharmaceutical industries. Methods: Recent literatures have been surveyed from PUBMED, GOOGLE SCHOLAR, etc. like search engines, for summarising detailed ongoing research on Annona muricata, which could be used in complementary and alternative cancer therapy. Conclusion: The high nutritional value and pharmacological potential of Annona muricata turn it into a very good candidate for different health-related applications. There exist promising benefits of phytochemicals present in soursop for the treatment and prevention of a number of health conditions, underscoring its importance in functional foods and medicines development.

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