JPTRM Vol. 8 No. 2 (November 2020)

Permanent URI for this collection

Now showing 1 - 1 of 1

Molecular Docking Approach to Identify Potential AntiCandidal Potential of Curcumin.
(Chitkara University Publications, 2020-11-17) Nidhi Rani; Prerna Sharma; Praveen Kuma
Background: Candida albicans is a kind of fungus that can lead to mortality. In the presence of the enzyme Lanosterol-demethylase, Ergosterol, the major sterol in the fungal cell membrane, is the resulting product of Lanosterol (Cytochrome P450DM). Purpose: Azole antifungal drugs target this enzyme as a target enzyme. The work included selecting and modelling the target enzyme. Cucumin’s inhibitory effect on Cytochrome P450 was tested utilising molecular docking experiments. Methods: Chem sketch was used to create compound structures, and Molergo Virtual Docker was used to do molecular docking. Results: All of the curcumin and conventional medicines, such as Ketoconazole, Clotrimazole, and Miconazole, have interaction with 14-demethylase amino acid residues, Haem and water molecules in the target site, as per the docking research.