Browsing by Author "Amit Sharma"

Now showing 1 - 7 of 7
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    A Review on Medication Errors
    (Chitkara University Publications, 2015-11-17) Madhaw Dwivedi; Amit Sharma; Sandeep Arora
    Role of clinical pharmacist is to provide optimal pharmaceutical care for individual patients and optimal pharmaceutical care is attained when the right drug in the correct dosage and quality reaches the right patients at the right point in time with the right information. Any preventable event that may cause or lead to inappropriate medication use or patient harm during medication to user is called medicational error and is in the control of the health care professional, patient and consumer. In this review on medication errors, prescr-ibing errors (67 %), administration errors (25%), dispensing errors (08%) were found on the basis of review of literature.Prescribing errors are the prime cause of MEs that further leads to subsequent dispensing and administration errors. Medication errors are common cause of adverse drug events or subtherapeutic outcomes of pharmaceutical care.
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    Eco-Friendly Solvent-Free Infrared (IR) Spectroscopic Method for Voglibose Determination
    (Chitkara University Publications, 2024-04-20) Kritika Verma; Shibam Das; Amit Sharma; Rohit Bhatia
    Background: Voglibose, an α-glucosidase inhibitor used in diabetes management, traditionally requires chromatographic or solvent-based methods for quantification. However, IR spectroscopy offers a rapid, non-destructive, and cost-effective alternative without chemical waste. This method enhances sustainability while maintaining accuracy and sensitivity in pharmaceutical analysis. Purpose: To validate a method for quantifying voglibose using Fourier-transform infrared (FTIR) spectroscopy, emphasizing its environmental benefits and applicability in academic and industrial settings. Methods: The FTIR spectroscopy method was developed without the use of organic solvents, requiring only grinding of powders for pellet preparation. Spectra were recorded in absorbance mode within the 868.47–829.40 cm⁻¹ region, based on Beer’s law, to construct a calibration model. Validation was performed according to International Council for Harmonization (ICH) guidelines. Results: The method demonstrated linearity with a regression coefficient of 0.996. It was precise, accurate (average recovery of 98.68%), and robust across a concentration range of 0.5 to 5.0 mg. The method minimizes waste generation, offering an eco-friendly alternative to conventional techniques. Conclusion: The validated FTIR spectroscopy method for voglibose quantification in raw materials is a reliable, accurate, and environmentally sustainable alternative for standard quality control processes in both academic and industrial applications.
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    Formulation Strategies for Nose-to-Brain Drug Delivery
    (Chitkara University Publications, 2022-05-07) Manisha Vohra; Mohammad Amir; Amit Sharma; Sheetu Wadhwa
    Background: Neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, Multiple Sclerosis, Dementia, and others are becoming more common globally due to people’s changing lifestyles. Furthermore, the presence of the Blood-Brain barrier and other limitations of oral and other routes of administration makes drug delivery to the brain somewhat tricky.As a result, numerous novel drug delivery systems are being developed for drug administration to the brain. However, nose-to-brain administration is one of the most effective, safe, and non-invasive methods. Purpose: To discuss nose-to-brain deliveryas a novel drug delivery system in the treatment of various brain disorders and to provide information about various formulation strategies designed to deliver the drug to the brain effectively. Methods: A preliminary search was conducted in the PubMed, OVID Medline, Embase, ScienceDirect, Web of Science, and Google Scholar databases using keywords such as “Intranasal delivery, nose-to-brain drug transport, formulations for intranasal delivery.” Results: Various marketed formulations for nose-to-brain drug delivery are listed in this review, like naringenin, donepezil, pentamidine, rivastigmine,efavirenz, desvenlafaxine,lamotrigine, haloperidol,nimodipine, olanzapine, valproic acid, ovalbumin,clonazepam,fentanyl citrate, nifedipine in the form of poloxamer chitosan-based nano-formulation, nano-emulsion, chitosan niosomes, chitosan containing emulsion, solid-lipid nanoparticles,PLGA-chitosan nanoparticles, solution, mucoadhesive microemulsion,nanostructured lipid carriers, cationic liposomes,peptide-attached liposomes, multimellar liposomes with their research findings in treating various brain disorders. Conclusion: This review discusses nose-to-brain drug delivery processes, the pathway for its action, advantages over other delivery routes, barriers to this system, and current formulation strategies for nose-to-brain transport.
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    Review on Bullous Pemphigoid: Fixed Drug Eruption or Autoimmune Disorder
    (Chitkara University Publications, 2024-11-20) Adarsh Keshari; Kriti Jain; Roshan Pandey; Ayush Mishra; Sarita Jangra; Amit Sharma; Bhavesh Dharmani; Bisman; Thakur Gurjeet Singh
    Background: Bullous pemphigoid is a blistering disease of autoimmune nature predominantly affecting the geriatric population. It is characterized by blister formation at the subepidermal level, due to autoantibodies at the dermo-epidermal junction targeting proteins BP180XV11 and BP230. Mainly an autoimmune condition, diagnosis and treatment get complicated as it overlaps with drug-induced hypersensitivity reactions, including fixed drug eruption. Unlike Bullous Pemphigoid, it is a condition of localized hypersensitivity mediated by T cells. Purpose: The review tries to establish Bullous Pemphigoid as an autoimmune condition separate from fixed drug eruption. It is centered on the causative role of medications, which include diuretics, antibiotics, and dipeptidyl peptidase-4 inhibitors, in drug-induced bullous pemphigoid. Besides, it examines genetic, immunological, and environmental etiologies of the disease and delineates clinical and diagnostic characteristics of Bullous Pemphigoid and fixed drug eruptions. Method: A systematic analysis of current literature was performed, focusing on the pathophysiology, immunological mechanisms, and histopathological differences between Bullous Pemphigoid and fixed drug eruptions. The review also examines the role of medications, genetic predispositions such as specific human leukocyte antigen haplotypes, and the diagnostic utility of histopathological and immunological methods like direct immunofluorescence. Results: Autoantibodies against BP180 and BP230 in bullous pemphigoid initiate inflammatory cascades, causing subepidermal blistering and eosinophilic infiltration. Fixed drug eruption involves basal cell necrosis and localized lymphocytic infiltration. Drugs like dipeptidyl peptidase-4 inhibitors exacerbate bullous pemphigoid through immune modulation and oxidative stress. Genetic susceptibility plays a significant role, and immunological tests such as direct immunofluorescence help distinguish the two conditions. Conclusion: Bullous pemphigoid is a distinct autoimmune disease with unique immunopathological mechanisms compared to fixed drug eruption. Understanding its pathogenesis, drug interactions, and diagnostic methods enhances accurate diagnosis and management of both spontaneous and drug-induced bullous pemphigoid.
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    Role of Silver and Gold Nanoparticles in the Management of Diabetes: Current Trends and Perspectives
    (Chitkara University Publications, 2022-11-10) Mohammad Amir; Manisha Vohra; Amit Sharma; Sheetu Wadhwa
    Background:Diabetes mellitus is a severe metabolic disease in which a person’s body cannot control the glucose level in the blood; it results from a defect in insulin secretion, insulin action, or both. Nanotechnology is a rising area in pharmaceutical sciences as nanoparticles are reported to enhance drug efficacy obtained from plant sources through green synthesis. Purpose: The purpose of this review is to focus on the antidiabetic potential of various metallic nanoparticles like silver, gold, copper, and selenium by using their secondary metabolites like tannins, alkaloids, saponins, and steroids. The advantages of green nanoparticle synthesis are that they are eco-friendly, high temperature is not required, can be used on large-scale synthesis, and are cost-effective. Methods:A preliminary search was conducted in PubMed, OVID Medline, Embase, ScienceDirect, Web of Science, and Google Scholar databases using keywords such as “Diabetes, nanoparticles, metallic nanoparticles, gold nanoparticles, silver nanoparticles.” Results: This review includes various marketed formulations of silver and gold nanoparticles particles obtained from various biological sources like allium cepa, argyreia nervosa, callophyllumtomentosum, punica granatum, cassia auriculate, saracaasoka, gymnemasylvestre, etc. along with their research findings for reducing the antidiabetic activity. Conclusion:This review contains details about the silver and gold nanoparticles obtained from various biological sources used to treat diabetes.
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    Scary Truth of Medical Personnel in India
    (Chitkara University Publications, 2022-05-07) Amit Sharma; Ian Osoro; Ruby Gangwar
    India is having a lack of adequate medical personnel in a country with a second largest population stands at an alarming level. According to National Health Profile report by the Ministry of Health, Government of India, the situation in India related to the ratio of doctors available and actually practicing is really critical in 2018. The doctor density is far worse in the country’s poorer states. India requires over 7.47 lakh more allopathic doctors to meet World Health Organization (WHO) prescribed norms for the doctor-population ratio.
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    The Impact of Maternal Obesity on the Development and Outcomes of Congenital Masses: A Review
    (Chitkara University Publications, 2024-04-20) Sarita Jangra; Amit Sharma; Thakur Gurjeet Singh; Bhavesh Dharmani; Tanya Sood; Kritika Sharma; Bhupinder Bhyan; Yousef Saeed Alqarni; Fahad Thabet Alsulami
    Background: The global prevalence of obesity has risen sharply, including among pregnant women, contributing to a significant increase in obstetric complications and adverse birth outcomes. One such concern is the development of congenital anomalies, which include cystic, solid, or vascular malformations. These anomalies are influenced by maternal factors such as pre-pregnancy malnutrition, inadequate folic acid intake, iodine deficiency, consanguineous marriages, insufficient immunization, and exposure to teratogens like alcohol. Addressing the high morbidity associated with these abnormalities requires a deep understanding of their anatomical and etiological factors. Purpose: This review aims to examine the impact of maternal obesity on the development and outcomes of congenital masses. It seeks to identify mechanisms underlying these malformations, assess their prevalence, and explore strategies for prevention and management. Method: A comprehensive literature review was conducted, focusing on studies that link maternal obesity with congenital anomalies. Relevant articles were identified from databases such as PubMed, Scopus, and Web of Science using keywords like “maternal obesity,” “congenital masses,” “foetal malformations,” and “pregnancy outcomes.” Results: Maternal obesity was associated with an increased risk of congenital anomalies due to factors such as altered metabolic states, inflammation, and suboptimal nutrient levels. Early diagnosis and intervention were identified as critical for improving outcomes. Conclusion: Maternal obesity significantly impacts the development and outcomes of congenital masses. Effective prevention strategies, such as nutritional counselling, obesity management, and early screening programs, are essential to mitigate these risks and improve maternal and neonatal health outcomes.