JPTRM Vol. 9 No. 2 (November 2021)

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Browsing JPTRM Vol. 9 No. 2 (November 2021) by Author "Amarjot Kaur Grewal"

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    Therapeutic Implication of Herbal Phytoconstituents in Alzheimer’s Disease
    (Chitkara University Publications, 2021-11-08) Vivek Rihal; Heena Khan; Amarjot Kaur Grewal; Thakur Gurjeet Singh
    Introduction: Herbal plants have been widely used in traditional medicines for improving cognitive decline and age-related loss of memory since ancient times. Medicinal plants, it is claimed, contain various active components, and they have a widely used synthetic medication option for treating cognitive and associated issues. Herbal medicines have aided in advancing medicine, and several innovative pharmaceuticals have already developed. For example, much research has backed the use of phytoconstituents in herbal medicines to treat Alzheimer’s disease (AD). Progressive memory loss, linguistic difficulties, melancholy, anxiety, mood swings, and psychosis are some of these symptoms. Objective: A systemic literature review of Bentham, Scopus, PubMed, Medline, and EMBASE (Elsevier) database was carried out to understand the study till March 2021. Conclusion: Although neurofibrillary tangle and cholinergic dysfunction, -amyloid plaquesdevelopment are critical features of AD, it is also linked to oxidative damage, disruption of other neurotransmitters, high levels of AGEs, neuroinflammation, hereditary and environmental variables. On the one hand, because of this complex etiology, responses to routinely used medications like memantine, donepezil, galantamine, and rivastigmine are unpredictable and frequently poor. On the other hand, their nonspecific anti-inflammatory and antioxidant effect and particular cholinesterase inhibitory activity support the use of herbal medications. Herbal drugs are also gaining popularity as a result of their supposed efficacy, safety, and accessibility.
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    Therapeutic Implication of Herbal Phytoconstituents in Stroke
    (Chitkara University Publications, 2021-11-08) Heena Khan; Vivek Rihal; Thakur Gurjeet Singh; Amarjot Kaur Grewal
    Introduction: Ischemic stroke is a prominent global cause of death and disability. Other than employingischemic stroke treatment with recombinant tissue plasminogen activator, which must be administered within 3 hours of an acute incident and carries a high risk of hemorrhagic complications, there is currentlya few effective stroke treatment should be done. Herbal medicines, mainly derived from plants, are an excellent source for developing novel therapeutic agents for a wide range of human illnesses. In additionally, the multifaceted influence of herbal medicine and its active ingredients on stroke aetiology may indicate a bright future for natural medicine in stroke therapy. Objective: Herbal medications are effective in stroke therapy because of their anti apoptotic, neuroprotective, anti inflammatory, and vascular protecting effects. Although herbal remedies are often thought of as safe and effective, there is a frequent misconception that if a treatment is effective, it must have side effects. As a result, herbal remedies are either useless or have undesirable side effects as medications. A sizeable portion of the populations in many developed countries relies on traditional healers and their supply of medicinal plants to suit their medical needs. Conclusion: Even after due to historical and cultural factors, herbal medicines have typically retained their popularity despite the advent of modern medicine alongside such ancient therapies. Additionally, herbal remedies are more advantageous for chronic health issues like stroke. This review looks at the possible mechanism of Action for the Valuable Effects of Herbal Medicines in stroke patients.