JPTRM Vol. 8 No. 2 (November 2020)

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Protein Kinase Structure, Function, and its Binding Sites for Understanding the Role in Anticancer Therapy
(Chitkara University Publications, 2020-11-17) Adarsh Sahu
Background: Protein kinases are involved in regulating different aspects of metabolism including cell growth, differentiation and regulation of cell cycle. Deregulated protein kinases are thought to affect various forms of tumor growth. The advent of protein kinase inhibitors has caused a great shift in the way we treat cancer. Purpose: There were several inhibitors of protein kinases that had been approved by the FDA in the last few decades. Therefore the need of the hour is to know the structure of the protein kinase to design the effective therapy for cancer treatment. Interaction of the drug with the protein is successful if the drug binds to the cavity of the receptor or protein and brings conformational changes, therefore the binding site in the protein should be well understood. Conclusion: Thus in this mini review we have systematically discussed the structure of protein kinase and their binding sites so the future designing of the potential molecules should have better efficacy.