JPTRM Vol. 3 No. 2 (November 2015)

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https://demodspace.chitkara.edu.in/handle/123456789/129

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Browsing JPTRM Vol. 3 No. 2 (November 2015) by Author "Sandeep Arora"

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    A Review on Medication Errors
    (Chitkara University Publications, 2015-11-17) Madhaw Dwivedi; Amit Sharma; Sandeep Arora
    Role of clinical pharmacist is to provide optimal pharmaceutical care for individual patients and optimal pharmaceutical care is attained when the right drug in the correct dosage and quality reaches the right patients at the right point in time with the right information. Any preventable event that may cause or lead to inappropriate medication use or patient harm during medication to user is called medicational error and is in the control of the health care professional, patient and consumer. In this review on medication errors, prescr-ibing errors (67 %), administration errors (25%), dispensing errors (08%) were found on the basis of review of literature.Prescribing errors are the prime cause of MEs that further leads to subsequent dispensing and administration errors. Medication errors are common cause of adverse drug events or subtherapeutic outcomes of pharmaceutical care.
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    Development, physicochemical characterization and in-vitro evaluation of herbal sunscreen lotion
    (Chitkara University Publications, 2015-11-17) Sandeep Arora; Neelam Sharma; Akanksha Mahajan; Jaspreet Kaur; Sukhbir Singh
    Ultraviolet radiations have shorter wavelengths and can reach earth’s surface through penetrating clouds. UV-A rays leads to aging while UV-B rays causes burning of skin. Sunscreens protect the skin from harmful effects of sun including appearance of erythema, premature photo-ageing and facilitate to diminish the manifestation of facial red veins and blotchiness. In this investigation, herbal sunscreen was prepared using Shea butter, almond oil, raspberry oil, jojoba oil, zinc oxide and titanium dioxide as active ingredients. Fabricated lotions were evaluated for physicochemical parameters i.e. color, pH, viscosity and spreadability. Sun protection efficacy of lotion was determined in term of sun protection factor (SPF) by in-vitro spectrophotometric method. Total 10 formulations were made with different compositions F1-F10. The pH of formulations ranges from 6.10 (F6) to 8.34 (F5). The viscosity of formulations ranges from 1500 (F1) to 3586 (F10). The spreadability of formulations ranges from 10.56±0.8 (F1) to 30.65±0.7 (F10). The physicochemical parameters of formulation F6 and F10 were found to be in controlled range justifying its compatibility with skin and confirming good cosmetological property. Stability study of optimized lotion was performed after storage of formulation at 25°C and 60 % RH as well as 40°C and 75 % RH for three months. Stability of lotion was evaluated on the basis of changes in physicochemical parameters i.e. color, pH, viscosity and spreadability and SPF. F10 has SPF value of 15.71±0.07 (medium protection sunscreen). The optimized formulations might provide good moisturizer, emollient, anti-ageing and anti-wrinkle effect with good sun protection.
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    Mannich Bases of 2-Substituted Benzimidazoles – A Review
    (Chitkara University Publications, 2015-11-17) Ritchu Sethi; Sandeep Arora; Neelam Jain; Sandeep Jain
    Mannich bases are the end products of mannich reaction and are known as beta amino ketone carrying compounds. Mannich reaction is a carbon carbon bond forming nucleophilic addition reaction which helps in synthesizing N-methyl derivatives and many other drug molecules. Mannich base derivatives of benzimidazoles possess many pharmacological properties such as anti-oxidant, anti-inflammatory, anticancer, antiviral, anthelmintic and play an important role in medical field. As these drugs are clinically useful in treatment of microbial infections and exhibit other therapeutic activities also, so this encouraged the development of more potent, novel and clinically significant compounds. In this review synthesis and various biological activities of new mannich bases of benzimidazole derivatives reported is discussed.