JPTRM Vol. 12 No. 1 (May 2024)

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Browsing JPTRM Vol. 12 No. 1 (May 2024) by Author "Josephat Gaudence Kipesha"

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    Understanding the Role of Muscle Coordination Impairments in Central Nervous System Disorders
    (Chitkara University Publications, 2024-04-20) Josephat Gaudence Kipesha; Harshpreet kaur; Navneet Khurana; Neha Sharma
    Background: The central nervous system (CNS) regulates the precise activation of motor units, which is vital for muscle coordination and goal-directed movement. The CNS modulates motor unit firing rates to control force production during muscle contraction. Many CNS diseases, such as Alzheimer’s disease, Huntington’s disease, Parkinson’s disease, and anxiety-related disorders, are linked to abnormalities in muscle coordination. Purpose: This review examines the complex connection between CNS disorders and impairments in muscle coordination, highlighting the roles of motor performance, neurodegeneration, and cerebellar function. Methods: A comprehensive review of recent literature was conducted to analyze the neurophysiological mechanisms underlying motor dysfunction. Studies involving kinematic analyses describing movement abnormalities in anxiety and depression were reviewed. Results: Neurodegenerative processes contribute to muscular dysfunction, often occurring without anatomical alterations in muscle tissue. Declining motor performance and neurodegenerative changes suggest that early motor impairments may serve as potential indicators of CNS pathology. Conclusion: Understanding the link between CNS disorders and muscle coordination impairments is crucial for distinguishing drug-induced muscular effects from symptoms of neurological diseases, guiding the development of more targeted treatments.