JPTRM Vol. 3 No. 1 (May 2015)

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https://demodspace.chitkara.edu.in/handle/123456789/130

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Browsing JPTRM Vol. 3 No. 1 (May 2015) by Author "Sandeep Arora"

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    A Review on Role of Advanced Glycation End products (AGEs) in Rheumatoid Arthritis
    (Chitkara University Publications, 2015-05-20) Ravinder Kumar; Sandeep Arora; Pratima Syal; Mayank Sippy
    Rheumatoid arthritis (RAa) is a systemic inflammatory connective tissue disease with polyarthritis as a prominent feature; however, extra-articular symptoms and signs are always present. Aadvanced glycation end products with ability of cross-linking of proteins characteristic fluorescence and reaction with AaGEe-specific receptor RAaGEe (receptor for AaGEes). AaGEes action as well as AaGEe formation is directly related to both to inflammation and oxidative stress. RAaGEe is a 35-kDa polypeptide whose gene is located at the junction of the class II and III HLAla regions on chromosome. ligation of RAaGEe has been shown to activate p21ras and mitogen-activated protein (MAaP) kinase, and stimulate nuclear translocation of the transcription factor NF-κB, thereby, resulting in the transcription of target genes thus may induce chronic cellular activation and tissue damage.
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    Synthesis,Characterization and Biological studies on Mannich Bases of 2-Substituted Benzimidazole Derivatives
    (Chitkara University Publications, 2015-05-20) Ritchu Sethi; Sandeep Arora; Sandeep Jain; Neelam Jain
    In the present study novel derivatives of 2-substituted benzimidazoles were prepared via Mannich reaction and evaluated for their in vitro antimicrobial activity against two gram negative strains (Escherichia coli and Pseudomonas aeruginosa), two gram positive strains (Bacillus subtilis and Staphylococcus aureus) and fungal strains (Candida albicans and Aspergillus niger).The synthesized compounds were also screened for antioxidant activity.The newly synthesized compounds were characterized by spectral and analytical techniques.The results revealed that all the synthesized compounds have a significant antioxidant and biological activity against the tested microorganisms.