Ritchu SethiSandeep AroraNeelam JainSandeep Jain2025-12-162025-12-162015-11-172321-22172321-2225https://doi.org/10.15415/jptrm.2015.32008https://demodspace.chitkara.edu.in/handle/123456789/185Mannich bases are the end products of mannich reaction and are known as beta amino ketone carrying compounds. Mannich reaction is a carbon carbon bond forming nucleophilic addition reaction which helps in synthesizing N-methyl derivatives and many other drug molecules. Mannich base derivatives of benzimidazoles possess many pharmacological properties such as anti-oxidant, anti-inflammatory, anticancer, antiviral, anthelmintic and play an important role in medical field. As these drugs are clinically useful in treatment of microbial infections and exhibit other therapeutic activities also, so this encouraged the development of more potent, novel and clinically significant compounds. In this review synthesis and various biological activities of new mannich bases of benzimidazole derivatives reported is discussed.enMannich BasesSubstituted BenzimidazolesPharmacological ActivitiesArticle