Nidhi RaniPrerna SharmaPraveen Kuma2025-12-182025-12-182020-11-172321-22172321-2225https://doi.org/10.15415/jptrm.2020.82008https://demodspace.chitkara.edu.in/handle/123456789/246Background: Candida albicans is a kind of fungus that can lead to mortality. In the presence of the enzyme Lanosterol-demethylase, Ergosterol, the major sterol in the fungal cell membrane, is the resulting product of Lanosterol (Cytochrome P450DM). Purpose: Azole antifungal drugs target this enzyme as a target enzyme. The work included selecting and modelling the target enzyme. Cucumin’s inhibitory effect on Cytochrome P450 was tested utilising molecular docking experiments. Methods: Chem sketch was used to create compound structures, and Molergo Virtual Docker was used to do molecular docking. Results: All of the curcumin and conventional medicines, such as Ketoconazole, Clotrimazole, and Miconazole, have interaction with 14-demethylase amino acid residues, Haem and water molecules in the target site, as per the docking research.enAntifungal medicationsCandida albicans14α-demethylaseMolecular dockingMolecular modelingArticle