Formulation And Characterization of Carageenan Gels Encapsulating Amphotericin B And Lactobacillus acidophilus Against Candidal Vaginitis
| dc.contributor.author | R. Kaur | |
| dc.contributor.author | M. Khurana | |
| dc.contributor.author | M. Bindal | |
| dc.contributor.author | A. Sharma | |
| dc.date.accessioned | 2025-12-06T04:49:19Z | |
| dc.date.available | 2025-12-06T04:49:19Z | |
| dc.date.issued | 2017-10-02 | |
| dc.description.abstract | The present study is concerned with the development and characterization of bioadhesive carageenan gel encapsulating Amphotericin B and Lactobacillus acidophillus, prepared by graft co-polymeriztion against Candidal vaginitis. Intravaginal gel systems based on bioadhesive polymer (carrageenan) were characterized with respect to swelling index, bioadhesive strength, percent encapsulation and in vitro drug release antimicrobial studies. A marked increase in swelling index of gel encapsulating Lactobacillus was found to be 1.9±0.35. The percent encapsulation of drug was found to be 98.63%±.0.2% and that of Lactobacillus was 91.81 ±0.01. The viability was observed for interval of 6 hrs on trypton soya agar and showed that viability was highly conserved till 4 hrs. The antimicrobial study of gels encapsulating Amphotericin B and Lactobacillus showed that carageenan gel can inhibit Candida albicans upto a maximum extent. Bioadhesivity study also conducted for gels that showed a bioadhesivity of 84.66% ±.0.5% with drug, 88.66% ±.02% with Lactobacillus. In-vitro drug release showed a sustained type release of drug from the polymer i.e. there was initial burst of Amphotericin B up to 5 hours, after which there was a sustained release upto 10 days. Thus it has been concluded from the present study that bioadhesive gels encapsulating Amphotericin B can act as promising drug carriers along with Lactobacillus against candidal vaginitis. | |
| dc.identifier.issn | 2393-8536 | |
| dc.identifier.issn | 2393-8544 | |
| dc.identifier.other | https://doi.org/10.15415/jmrh.2017.41004 | |
| dc.identifier.uri | https://demodspace.chitkara.edu.in/handle/123456789/92 | |
| dc.language.iso | en | |
| dc.publisher | Chitkara University Publications | |
| dc.subject | Candidal Vaginitis | |
| dc.subject | Carageenan | |
| dc.subject | Swelling index | |
| dc.subject | Encapsulation | |
| dc.subject | Bioadhesivity | |
| dc.title | Formulation And Characterization of Carageenan Gels Encapsulating Amphotericin B And Lactobacillus acidophilus Against Candidal Vaginitis | |
| dc.type | Article |