An Ethanol-Based Proliposome Technology for Enhanced Delivery and Improved “Respirability” of Antiasthma Aerosols Generated Using a Micropump Vibrating-Mesh Nebulizer

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dc.contributor.authorAbdelbary M.A. Elhissi
dc.contributor.authorJasmeet Brar
dc.contributor.authorMohammad Najlah
dc.contributor.authorSimon A. Roberts
dc.contributor.authorAhmed Faheem
dc.contributor.authorKevin M.G. Taylor
dc.date.accessioned2025-12-15T08:54:07Z
dc.date.available2025-12-15T08:54:07Z
dc.date.issued2013-11
dc.description.abstractSalbutamol sulphate liposomes were generated using ethanolbased proliposomes followed by nebulization using an Aeroneb Pro vibrating-mesh nebulizer. The droplet size, output and fine particle fraction (FPF) of the drug incorporated in liposome formulation were compared to those of a conventional drug solution. Aerosol output was determined gravimetrically and drug output was analyzed by using high performance liquid chromatography. The potential of aerosol deposition in deep lung was evaluated using inertial impaction and laser diffraction. The effect of formulation surface tension on the aerosol performance was studied. Output and FPF were improved using liposomes compared to the conventional solution, for instance, FPF values were 57.85% and 45.81% respectively. The volume median diameter as measured by laser diffraction was respectively 3.44 μm and 3.22 μm; however, the higher FPF of the liposome formulation is justified by the lower polydispersity of its aerosol. The improved aerosol performance using liposomes was attributed to the reduction of surface tension caused by the presence of phospholipid. This is the first study that demons trates the ability of liposomes to improve the nebulized drug output and FPF.
dc.identifier.issn2321-2217
dc.identifier.issn2321-2225
dc.identifier.otherhttps://doi.org/10.15415/jptrm.2013.12010
dc.identifier.urihttps://demodspace.chitkara.edu.in/handle/123456789/157
dc.language.isoen
dc.publisherChitkara University Publications
dc.subjectFormulation
dc.subjectInhalation
dc.subjectLung
dc.subjectPulmonary
dc.subjectSolution
dc.titleAn Ethanol-Based Proliposome Technology for Enhanced Delivery and Improved “Respirability” of Antiasthma Aerosols Generated Using a Micropump Vibrating-Mesh Nebulizer
dc.typeArticle

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JPTRM Vol. 1 No. 2 (November 2013)