Antihepatotoxic Potential of Citrullus colocynthis Root Extract, Fractions and Isolated Compounds

Simple item page
dc.contributor.authorAlok Mukerjee
dc.contributor.authorShanti Bhushan Mishra
dc.contributor.authorShubhini Saraf
dc.date.accessioned2025-12-15T09:42:19Z
dc.date.available2025-12-15T09:42:19Z
dc.date.issued2014-11-30
dc.description.abstractMedicinal plants are considered to be effective and safe alternative treatment for liver toxicity. The article reveals the hepatoprotective activity of the ethanolic extract of the roots of the Citrullus colocynthis commonly known as INDRYAN using carbon tetrachloride (CCl4) experimental model in albino rats. After receiving significant protection of Ethanolic extract on liver the extract further undergone fractionation into three fractions & the activity was localized in the toluene fraction. These on purification led to the isolation of two pure compounds which were identified as – Cucurbitacin B[1] and Colocynthin [2]. The pure compound shows reduction in enzymatic level viz. (SGOT 68.09%, SGPT 63.64%, ALP 76.81%, BL 68.22%) and (SGOT 71.28%, SGPT 65.24%, ALP 80.68%, BL 54.92%) at 50 mg/ kg dose respectively whereas drug Silymarin showed reduction as (SGOT 79.73%, SGPT 74.26%, ALP 87.88%,BL 82.75% ) at 25 mg/kg dose level. On comparing the obtained data it was observed that the roots of C. colocynthis Sch. exhibited significantly better hepatoprotective activity, thus justifying the traditional claims.
dc.identifier.issn2321-2217
dc.identifier.issn2321-2225
dc.identifier.otherhttps://doi.org/10.15415/jptrm.2014.22009
dc.identifier.urihttps://demodspace.chitkara.edu.in/handle/123456789/171
dc.language.isoen
dc.publisherChitkara University Publications
dc.subjectCitrullus colocynthis
dc.subjecthepatoprotective
dc.subjecttoluene fraction
dc.subjectisolation
dc.subjectethanolic extract.
dc.titleAntihepatotoxic Potential of Citrullus colocynthis Root Extract, Fractions and Isolated Compounds
dc.typeArticle

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
JPTRM Volume 2 Issue 2 002.pdf
Size:
436.95 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed to upon submission
Description:
Download

Collections

JPTRM Vol. 2 No. 2 (November 2014)