Development and Validation of Method for the Estimation of Telmisartan as Active Pharmaceutical Ingredient in Tablet Dosage form and Prepared Spherical Agglomerates by RP-HPLC

Simple item page
dc.contributor.authorSharma Shaina
dc.contributor.authorSoni Varinder
dc.contributor.authorRahar Sandeep
dc.contributor.authorBhatia Nitish
dc.date.accessioned2025-12-16T08:51:55Z
dc.date.available2025-12-16T08:51:55Z
dc.date.issued2016-05-07
dc.description.abstractThe Present work was designed to develop and validate an accurate, precise and rapid method for the estimation of Telmisartan as Active Pharmaceutical Ingredient (API) as well as in tablet dosage form and prepared spherical agglomerates by RP-HPLC. The developed method was found to be simple, accurate, precise and sensitive. The separation was achieved on an Isocratic High Pressure Liquid Chromatography (HPLC) (Thermo Scientific) using pumps Jasco PU 2080 Plus, UV detector, column oven (Jasco), and a Reverse Phase C-18 (phenyl) Column (25 cm x 4.6 mm) i.d., particle size 5 μm. The HPLC system was run with flow rate: 0.8 ml/min Injection Volume: 10μl and run time: 10 min, Detector temp: 40 oC. The method was validated for specificity, precision, linearity, and accuracy, robustness, LOD and LOQ parameters. The recovery range was within the range of 99.0–102.0% and the method could be successfully applied for the routine analysis of the drug substance as well as the spherical agglomerates prepared by crystallo coagglomeration technique.
dc.identifier.issn2321-2217
dc.identifier.issn2321-2225
dc.identifier.otherhttps://doi.org/10.15415/jptrm.2016.41005
dc.identifier.urihttps://demodspace.chitkara.edu.in/handle/123456789/194
dc.language.isoen
dc.publisherChitkara University Publications
dc.subjectRP HPLC
dc.subjectMethod Development
dc.subjectTelmisartan
dc.subjecttablet
dc.subjectSpherical agglomerates
dc.subjectValidation
dc.titleDevelopment and Validation of Method for the Estimation of Telmisartan as Active Pharmaceutical Ingredient in Tablet Dosage form and Prepared Spherical Agglomerates by RP-HPLC
dc.typeArticle

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
JPTRM Volume 4 Issue 1 005.pdf
Size:
337.93 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed to upon submission
Description:
Download

Collections

JPTRM Vol. 4 No. 1 (May 2016)