Persea Americana’s Extract Could Offer Effective Treatment for Amyotrophic Lateral Sclerosis: A Hypothesis

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dc.contributor.authorSukriti Vishwas
dc.contributor.authorBushra Bashir
dc.contributor.authorNikhil B. Khandale
dc.contributor.authorSachin Kumar Singh
dc.contributor.authorUma Devi
dc.date.accessioned2025-12-19T08:54:02Z
dc.date.available2025-12-19T08:54:02Z
dc.date.issued2023-11-10
dc.description.abstractBackground: Amyotrophic lateral sclerosis (ALS) is a rare neurodegener-ative disease characterized by the degeneration of upper and lower motor neurons in the central and peripheral nervous systems. Several patholog-ical conditions, including neuroinflammation, oxidative stress, and mito-chondrial dysfunction, contribute to the degeneration of motor neurons. Despite extensive research, no current drug therapies have proven effec-tive in treating ALS. Purpose: This study explores the therapeutic potential of Persea americana (PA) Mill, commonly known as avocado, in the treatment of ALS. Methods: The review draws on pre-clinical and clinical studies that have demonstrated the neuroprotective effects of PA extracts (PAE) in diseas-es such as Alzheimer’s and Parkinson’s, highlighting the potential mechanisms that may be relevant to ALS. Results: Although no studies have directly investigated the effects of PA on ALS, the bioactive compounds in PA have shown promising results in mitigating neurodegenerative processes through their diverse biological activities. Conclusion: Based on existing evidence from related neurodegenerative conditions and the mechanisms involved in ALS pathology, it is hypothesized that PA extracts may offer a novel therapeutic avenue for ALS. Further research is required to validate the efficacy of PAE in man-aging ALS symptoms and slowing disease progression.
dc.identifier.issn2321-2217
dc.identifier.issn2321-2225
dc.identifier.otherhttps://doi.org/10.15415/jptrm.2023.112005
dc.identifier.urihttps://demodspace.chitkara.edu.in/handle/123456789/287
dc.language.isoen
dc.publisherChitkara University Publications
dc.subjectAmyotrophic lateral sclerosis
dc.subjectPersea americana mill extract
dc.subjectOxidative stress
dc.subjectNeuroinflammation
dc.subjectNeuroprotective effects
dc.titlePersea Americana’s Extract Could Offer Effective Treatment for Amyotrophic Lateral Sclerosis: A Hypothesis
dc.typeArticle

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JPTRM Vol. 11 No. 2 (November 2023)