Role of Protein Kinase C in Diabetic Complications

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dc.contributor.authorSimran
dc.contributor.authorAmarjot Kaur Grewal
dc.contributor.authorSandeep Arora
dc.contributor.authorThakur Gurjeet Singh
dc.date.accessioned2025-12-18T06:13:57Z
dc.date.available2025-12-18T06:13:57Z
dc.date.issued2019-11-05
dc.description.abstractDiabetes is the most common and systemic disorder associated with hyperglycemia which is the significant factor in the development of micro- and macrovascular changes. Many mechanistic approaches i.e. activation of Protein kinase C, glycation end products production, hexosamine pathway and polyol pathway induce cellular damage and lead to the development of diabetic complications like nephropathy, neuropathy, retinopathy, and myopathy. One of the adverse effects of long-lasting hyperglycemia is activation of PKC (intracellular signaling enzyme) and has become a field of great research interest. Hence, in this review special emphasis is placed on microvascular complications which are due to activation of PKC. Clinical trials have also been conducted using selective PKC inhibitors and have shown positive results against hyperglycemia.
dc.identifier.issn2321-2217
dc.identifier.issn2321-2225
dc.identifier.otherhttps://doi.org/10.15415/jptrm.2019.72011
dc.identifier.urihttps://demodspace.chitkara.edu.in/handle/123456789/236
dc.language.isoen
dc.publisherChitkara University Publications
dc.subjectDiabetes mellitus
dc.subjectHyperglycemia
dc.subjectPKC
dc.subjectMicrovascular complications
dc.subjectPKC inhibitors
dc.titleRole of Protein Kinase C in Diabetic Complications
dc.typeArticle

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JPTRM Vol. 7 No. 2 (November 2019)