Formulation, Optimization and Evaluation of Sustained Release Microspheres using Taguchi Design

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dc.contributor.authorSukhbir Singh
dc.contributor.authorSandeep Arora
dc.contributor.authorNeelam
dc.contributor.authorDharna Allawadi
dc.date.accessioned2025-12-15T09:17:27Z
dc.date.available2025-12-15T09:17:27Z
dc.date.issued2014-05
dc.description.abstractThe aim of present study is to prepare microspheres of eudragit RL 100 loaded with Nefopam Hydrochloride by single emulsion solvent evaporation technique. Taguchi L9 orthogonal array design has been used to optimize the composition and operating conditions for preparation of formulations. Nine batches (F1-F9) were prepared by taking three independent variables (X1- drug: polymer ratio, X2- stirring speed and X3- stirring time) at three levels (+1, 0, -1). Response variables studied for batches (F1-F9) were mean particle size (μm) (Y1), drug entrapment efficiency (% w/w) (Y2) and drug loading (% w/w) (Y3). Drug- polymer compatibility study was carried out by DSC and FTIR spectroscopy and indicates no physicochemical interaction. Microspheres were analyzed for morphological characteristics, mean particle size, drug entrapment efficiency, drug loading and in-vitro drug release. Percentage cumulative drug release for optimized batch F5 was found to be 85.421 ± 0.054 and followed higuchi model for release of drug.
dc.identifier.issn2321-2217
dc.identifier.issn2321-2225
dc.identifier.otherhttps://doi.org/10.15415/jptrm.2014.21001
dc.identifier.urihttps://demodspace.chitkara.edu.in/handle/123456789/163
dc.language.isoen
dc.publisherChitkara University Publications
dc.subjectTaguchi
dc.subjectResponse Variables
dc.subjectIndependent Variables
dc.subjectDrug Entrapment Efficiency
dc.subjectDrug Loading
dc.subjectHiguchi Model
dc.titleFormulation, Optimization and Evaluation of Sustained Release Microspheres using Taguchi Design
dc.typeArticle

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JPTRM Vol. 2 No. 1 (May 2014)