Pharmacokinetic Studies of Curcumin Based Pyrazoline MAO Inhibitors

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dc.contributor.authorVishnu Nayak Badavath
dc.contributor.authorVenkatesan Jayaprakash
dc.contributor.authorSusanta Kumar Mondal
dc.contributor.authorSandeep Arora
dc.contributor.authorOrlando Acevedo
dc.contributor.authorAbhishek Thakur
dc.contributor.authorRajasekhara Reddy Iska
dc.date.accessioned2025-12-18T09:50:22Z
dc.date.available2025-12-18T09:50:22Z
dc.date.issued2020-11-17
dc.description.abstractBackground: Curcumin is a natural phenolic compound obtained from Curcuma longa, with proven human monoamine oxidase (MAO) inhibitory activity, but due to its poor oral bioavailability, blood-brain barrier permeability and extensive metabolism in the liver, it has never been recognized as a drug candidate. Purpose: In this study, the structure-based-drug design (SBDD) was adopted to incorporate the structural features of Curcumin with an aim to improve drug permeability and metabolic stability. Method: A series of ferulic amides (half portion of curcumin) (1-3) and curcumin based pyrazolinescompounds (4-6) were designed and Curcumintested for their membrane permeability and liver microsomal metabolic stability in a various animal in an in-vitro assay system. Conclusion: All the designed compounds showed a significant enhancement in permeability and metabolic stability is achieved through chemical modification.
dc.identifier.issn2321-2217
dc.identifier.issn2321-2225
dc.identifier.otherhttps://doi.org/10.15415/jptrm.2020.82012
dc.identifier.urihttps://demodspace.chitkara.edu.in/handle/123456789/243
dc.language.isoen
dc.publisherChitkara University Publications
dc.subjectStructure-based-drug design
dc.subjectCurcumin based Pyrazoline analogues
dc.subjectFerulic acid amides
dc.subjectMDCK-II permeability studies
dc.subjectLiver microsomal metabolic stability studies
dc.titlePharmacokinetic Studies of Curcumin Based Pyrazoline MAO Inhibitors
dc.typeArticle

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JPTRM Vol. 8 No. 2 (November 2020)