Molecular Docking Approach to Identify Potential AntiCandidal Potential of Curcumin.
| dc.contributor.author | Nidhi Rani | |
| dc.contributor.author | Prerna Sharma | |
| dc.contributor.author | Praveen Kuma | |
| dc.date.accessioned | 2025-12-18T09:58:24Z | |
| dc.date.available | 2025-12-18T09:58:24Z | |
| dc.date.issued | 2020-11-17 | |
| dc.description.abstract | Background: Candida albicans is a kind of fungus that can lead to mortality. In the presence of the enzyme Lanosterol-demethylase, Ergosterol, the major sterol in the fungal cell membrane, is the resulting product of Lanosterol (Cytochrome P450DM). Purpose: Azole antifungal drugs target this enzyme as a target enzyme. The work included selecting and modelling the target enzyme. Cucumin’s inhibitory effect on Cytochrome P450 was tested utilising molecular docking experiments. Methods: Chem sketch was used to create compound structures, and Molergo Virtual Docker was used to do molecular docking. Results: All of the curcumin and conventional medicines, such as Ketoconazole, Clotrimazole, and Miconazole, have interaction with 14-demethylase amino acid residues, Haem and water molecules in the target site, as per the docking research. | |
| dc.identifier.issn | 2321-2217 | |
| dc.identifier.issn | 2321-2225 | |
| dc.identifier.other | https://doi.org/10.15415/jptrm.2020.82008 | |
| dc.identifier.uri | https://demodspace.chitkara.edu.in/handle/123456789/246 | |
| dc.language.iso | en | |
| dc.publisher | Chitkara University Publications | |
| dc.subject | Antifungal medications | |
| dc.subject | Candida albicans | |
| dc.subject | 14α-demethylase | |
| dc.subject | Molecular docking | |
| dc.subject | Molecular modeling | |
| dc.title | Molecular Docking Approach to Identify Potential AntiCandidal Potential of Curcumin. | |
| dc.type | Article |