Synthesis, antimicrobial evaluation and QSAR studies of p-amino benzoic acid derivatives

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dc.contributor.authorMeeta
dc.contributor.authorPradeep Kumar
dc.contributor.authorBalasubramanian Narasimhan
dc.date.accessioned2025-12-15T09:28:04Z
dc.date.available2025-12-15T09:28:04Z
dc.date.issued2014-05
dc.description.abstractA series of Schiff bases (1-16) and esters (17-27) of p-amino benzoic acid (PABA) was synthesized and its in vitro antimicrobial potential was evaluated by using tube dilution method. Compound 11 was found to be most promising antibacterial agent (pMICbs = 2.11 μM/ml) having antibacterial potential comparable to standard drug norfloxacin (pMICbs = 2.61 μM/ml) and may be taken as a lead compound for the development of novel antibacterial agents. QSAR analysis indicated that electronic parameters, total energy (Te) and energy of lowest unoccupied molecular orbital (LUMO) were found dominant in explaining the antimicrobial activity of synthesized compounds.
dc.identifier.issn2321-2217
dc.identifier.issn2321-2225
dc.identifier.otherhttps://doi.org/10.15415/jptrm.2014.21007
dc.identifier.urihttps://demodspace.chitkara.edu.in/handle/123456789/169
dc.language.isoen
dc.publisherChitkara University Publications
dc.subjectPABA
dc.subjectSynthesis
dc.subjectAntimicrobial
dc.subjectmt-QSAR
dc.subjectLOO method
dc.titleSynthesis, antimicrobial evaluation and QSAR studies of p-amino benzoic acid derivatives
dc.typeArticle

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JPTRM Vol. 2 No. 1 (May 2014)