Browsing by Author "Veerta Sharma"

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    Chemical Induced Rodent Model of Autism Spectrum Disorders
    (Chitkara University Publications, 2022-11-10) Kavita Chauhan; Veerta Sharma; Heena Khan; Amarjot Kaur; Thakur Gurjeet Singh
    The term Autism spectrum disorder (ASD) refers to a neuro-developmental disorder that include repetitive behaviours, extremely constrained interests and deficits in social communication. In the last ten years, the numerous epidemiological papers discussing connection between autism and environmental chemical exposures has significantly increased. These findings are crucial because they focus on modifiable risk factors that may open up new possibilities for the primary prevention of the autism-related disability, which is now recognised to be more strongly related to environmental factors than was previously thought. A variety of environmental factors have been known as significant factors relevant to aetiology of ASD, such as lead and mercury (heavy metals), PCB(organic contaminant) and phthalates and BPA. The most accurate animal model of autism among all other models is valproic acid-induced autism, which can reproduce almost all of the molecular and cellular changes seen in humans with ASD. This review provide insight into various diagnostic available for autism, pathophysiology of autism and animal model of autism to develop a pharmacological therapeutic intervention for the treatment of disease.
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    Current Status of Multi Drug Resistance- Tuberculosis: A Major Public-Health Threat
    (Chitkara University Publications, 2024-11-20) Deepak Kajla; Veerta Sharma; Ashi Mannan; Tanveer singh; Pankaj Kumar Singh
    Background: Rifampicin is the most effective first-line antibiotic for tuberculosis (TB). However, drug resistance, particularly multidrug-resistant TB (MDR-TB), poses a significant global health challenge. According to the World Health Organization (WHO), approximately 500,000 new TB cases in 2019 were resistant to treatment, with 78% showing multidrug resistance. India alone accounted for 27% of all MDR or rifampicin-resistant (RR) TB cases reported in 2020. MDR-TB, defined by resistance to at least isoniazid and rifampicin, is primarily driven by poor adherence to treatment, inappropriate antibiotic use, and transmission in crowded settings. Purpose: This review highlights the increasing threat of MDR-TB and underscores the need for alternative therapeutic strategies, improved diagnostic tools, and updated treatment guidelines to combat drug-resistant TB effectively. Methods: A literature-based analysis was conducted, focusing on recent WHO reports, updated guidelines, and emerging approaches in MDR-TB diagnosis and management, including molecular diagnostics, novel oral drugs, and adjunctive therapies such as nutritional and traditional support systems. Results: Recent WHO guidelines emphasize early detection using advanced molecular techniques and the use of repurposed oral anti-TB medications. These strategies show promise in enhancing disease control and patient outcomes. However, the implementation of new regimens requires further clinical evaluation. Integration of supportive care approaches such as nutrition and traditional therapies may contribute to a more holistic management of MDR-TB. Conclusion: The growing prevalence of MDR-TB and XDR-TB calls for urgent action in diagnosis, treatment, and patient support. While revised WHO strategies offer a promising framework, continued research and clinical trials are vital to optimize therapies and address global TB drug resistance effectively.
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    Mechanistic role of herbals as alternative therapy for epilepsy
    (Chitkara University Publications, 2022-05-07) Diksha Sharma; Veerta Sharma; Gaaminepreet Singh; Thakur Gurjeet Singh; Amarjot Kaur Grewal
    Botanicals and herbs have been used by people with epilepsy for ages in various cultures across the world. Patients in both developing and developed nations are currently using herbal remedies to manage seizures or side effects from antiepileptic medicines (AEDs). The deleterious effects of AED medication have a greater impact on the patient’s life than seizures. Alternative remedies should be used to treat and manage epilepsy because synthetic pharmaceuticals have risks. Epilepsy may be managed and treated using herbal medicines that have fewer negative effects than pharmaceutical medications. Therefore, the current review discusses about the herbal drugs used in treatment of epilepsy.