Browsing by Author "Sheetu Wadhwa"

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    Formulation Strategies for Nose-to-Brain Drug Delivery
    (Chitkara University Publications, 2022-05-07) Manisha Vohra; Mohammad Amir; Amit Sharma; Sheetu Wadhwa
    Background: Neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, Multiple Sclerosis, Dementia, and others are becoming more common globally due to people’s changing lifestyles. Furthermore, the presence of the Blood-Brain barrier and other limitations of oral and other routes of administration makes drug delivery to the brain somewhat tricky.As a result, numerous novel drug delivery systems are being developed for drug administration to the brain. However, nose-to-brain administration is one of the most effective, safe, and non-invasive methods. Purpose: To discuss nose-to-brain deliveryas a novel drug delivery system in the treatment of various brain disorders and to provide information about various formulation strategies designed to deliver the drug to the brain effectively. Methods: A preliminary search was conducted in the PubMed, OVID Medline, Embase, ScienceDirect, Web of Science, and Google Scholar databases using keywords such as “Intranasal delivery, nose-to-brain drug transport, formulations for intranasal delivery.” Results: Various marketed formulations for nose-to-brain drug delivery are listed in this review, like naringenin, donepezil, pentamidine, rivastigmine,efavirenz, desvenlafaxine,lamotrigine, haloperidol,nimodipine, olanzapine, valproic acid, ovalbumin,clonazepam,fentanyl citrate, nifedipine in the form of poloxamer chitosan-based nano-formulation, nano-emulsion, chitosan niosomes, chitosan containing emulsion, solid-lipid nanoparticles,PLGA-chitosan nanoparticles, solution, mucoadhesive microemulsion,nanostructured lipid carriers, cationic liposomes,peptide-attached liposomes, multimellar liposomes with their research findings in treating various brain disorders. Conclusion: This review discusses nose-to-brain drug delivery processes, the pathway for its action, advantages over other delivery routes, barriers to this system, and current formulation strategies for nose-to-brain transport.
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    Role of Silver and Gold Nanoparticles in the Management of Diabetes: Current Trends and Perspectives
    (Chitkara University Publications, 2022-11-10) Mohammad Amir; Manisha Vohra; Amit Sharma; Sheetu Wadhwa
    Background:Diabetes mellitus is a severe metabolic disease in which a person’s body cannot control the glucose level in the blood; it results from a defect in insulin secretion, insulin action, or both. Nanotechnology is a rising area in pharmaceutical sciences as nanoparticles are reported to enhance drug efficacy obtained from plant sources through green synthesis. Purpose: The purpose of this review is to focus on the antidiabetic potential of various metallic nanoparticles like silver, gold, copper, and selenium by using their secondary metabolites like tannins, alkaloids, saponins, and steroids. The advantages of green nanoparticle synthesis are that they are eco-friendly, high temperature is not required, can be used on large-scale synthesis, and are cost-effective. Methods:A preliminary search was conducted in PubMed, OVID Medline, Embase, ScienceDirect, Web of Science, and Google Scholar databases using keywords such as “Diabetes, nanoparticles, metallic nanoparticles, gold nanoparticles, silver nanoparticles.” Results: This review includes various marketed formulations of silver and gold nanoparticles particles obtained from various biological sources like allium cepa, argyreia nervosa, callophyllumtomentosum, punica granatum, cassia auriculate, saracaasoka, gymnemasylvestre, etc. along with their research findings for reducing the antidiabetic activity. Conclusion:This review contains details about the silver and gold nanoparticles obtained from various biological sources used to treat diabetes.