Browsing by Author "Samriti, Talluri Sriram"

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    Predicting The Potential of Convolvulus Pluricaulis Against Cognitive Dysfunction With The Help of Prediction of Activities Spectra of Substances Software
    (Chitkara University Publications, 2022-11-10) Vikas Sharma; Navneet Khurana; Sakshi Sharma; Soumik Chaudhury; Samriti, Talluri Sriram; Neha Sharma
    Objective: Cognitive dysfunction appertains to a loss in verbal, non-verbal learning, attention, working and short-term memory, motor functioning, problem-solving, and processing speed. The major objective of this study is to find out phytoconstituents obtained from Convolvulus Pluricaulis with the help of PASS software, which can be used in the treatment of cognitive dysfunction. Methods: PASS is important software used in this study to find out biological activity spectra of phytoconstituents of Convolvulus Pluricaulis in the amelioration of cognitive dysfunction. The predicted biological activity was also compared with marketed compounds like Rivastigmine, donepezil, memantine, and curcumin. Results: From the study, it was found that CP has great potential in the treatment of cognitive dysfunction. Many phytoconstituents of CP have free radical scavenging, antioxidant, and dementia treatment activity. Conclusion: In this research work, information was compiled with the help of PASS software of phytoconstituents of Convolvulus Pluricaulis for its potential against cognitive dysfunction. Further research is required to explore the potential of CP phytoconstituents in the treatment of cognitive dysfunction.
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    Prediction of the Anti-Parkinson’s Effect of Phytoconstituents from Mucuna Pruriens with the use of Prediction of Activities Spectra of Substances Software
    (Chitkara University Publications, 2022-11-10) Sakshi Sharma; Navneet Khurana; Vikas Sharma; Soumik Chaudhury; Samriti, Talluri Sriram; Neha Sharma
    Mucuna pruriens Linn is the most popular plant which has been used for a long time for treating many diseases. The plants shows wide pharmacological activities like antidiabetic, antineoplastic, antiepileptic, aphrodisiac, antimicrobial activities etc. It has wide use in the treatment of the Parkinson’s disease. The rationale behind this study is to discover the maximum activities over the selected phytoconstituent of the plant Mucuna pruriens which can be used in Parkinson’s disease. With the help of Prediction of activities spectra of substances (PASS) software activities which are useful in the management of Parkinson’s disease can be recognized. The mol file of the compounds was downloaded from Pubchem and the activity of the various compounds was speculated in the PASS software. From the data we have noted the Pa values of the compounds and the related activities of the compounds then we have predicted the reported activities of the compounds and from the table and graph we have observed the higher and lowest value of the compounds showing different activities and also observed which are the compounds which does not show the activities.