Browsing by Author "Ritchu Sethi"

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    Mannich Bases of 2-Substituted Benzimidazoles – A Review
    (Chitkara University Publications, 2015-11-17) Ritchu Sethi; Sandeep Arora; Neelam Jain; Sandeep Jain
    Mannich bases are the end products of mannich reaction and are known as beta amino ketone carrying compounds. Mannich reaction is a carbon carbon bond forming nucleophilic addition reaction which helps in synthesizing N-methyl derivatives and many other drug molecules. Mannich base derivatives of benzimidazoles possess many pharmacological properties such as anti-oxidant, anti-inflammatory, anticancer, antiviral, anthelmintic and play an important role in medical field. As these drugs are clinically useful in treatment of microbial infections and exhibit other therapeutic activities also, so this encouraged the development of more potent, novel and clinically significant compounds. In this review synthesis and various biological activities of new mannich bases of benzimidazole derivatives reported is discussed.
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    Synthesis,Characterization and Biological studies on Mannich Bases of 2-Substituted Benzimidazole Derivatives
    (Chitkara University Publications, 2015-05-20) Ritchu Sethi; Sandeep Arora; Sandeep Jain; Neelam Jain
    In the present study novel derivatives of 2-substituted benzimidazoles were prepared via Mannich reaction and evaluated for their in vitro antimicrobial activity against two gram negative strains (Escherichia coli and Pseudomonas aeruginosa), two gram positive strains (Bacillus subtilis and Staphylococcus aureus) and fungal strains (Candida albicans and Aspergillus niger).The synthesized compounds were also screened for antioxidant activity.The newly synthesized compounds were characterized by spectral and analytical techniques.The results revealed that all the synthesized compounds have a significant antioxidant and biological activity against the tested microorganisms.