Browsing by Author "Ritchu Babbar"

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    A Comprehensive Review on Therapeutic Potential of Benzimidazole: A Miracle Scaffold
    (Chitkara University Publications, 2020-05-20) Ritchu Babbar; Swikriti; Sandeep Arora
    Background: Benzimidazole is a category of heterocyclic aromatic compounds formed from the fusion of six membered benzene with five membered imidazolering. The moiety possesses diverse biological and clinical applications. A number of studies have shown that a varied substituent around the benzimidazole nucleus results in pharmacologically active compounds of therapeutic interest. Purpose: Owing to its number of pharmacological properties, this moiety is of choice of interest in designing and synthesis of new therapeutic compounds. The existence of the benzimidazole core in numerous groups of biological agents like antimicrobial, antiviral, antiparasitic, antihypertensive, anticancer, CNS stimulant as well as depressants has made important scaffold for development of many newer therapeutic agents. There is utmost need to understand the synthesis and associated role of benzimidazole derived compounds in different diseases. Therefore, in the present review, we attempt to discuss various derivatives of benzimidazole nucleus with different pharmacological activities. Conclusion: Benzimidazoles have played a great role in discovery of drug and development. Huge attempt has been made towards benzimidazole heterocyclic-based organic compounds with great excellence that resulted in drugs with enormous biological activity. Therapeutic drugs containing benzimidazole nucleus are used in building drugs that serve to be an active area of research. This article becomes a source that will lead to discovery of new opportunities for all researchers interested in benzimidazole-based heterocyclic medicinal chemistry.
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    Green Chemistry and Its Applications
    (Chitkara University Publications, 2024-11-20) Ritchu Babbar
    Green chemistry is defined as “the design of chemical products and methods that eliminate or remove the practice and generation of unsafe and hazardous materials”. It is also called Sustainable Chemistry. The exponential growth of the population has emerged in the drastic debilitation of non-renewable fossil resources and an enormous rise in atmospheric carbon dioxide which led to severe energy and environmental crisis. Consequently, it is highly urgent to develop renewable energy to meet the sustainable development of society. Many Chemical Industries mainly pharmaceuticals encounter critical environmental issues for many years. Most of the chemical products have good applications but these compounds produce hazardous waste that is not eco-friendly. Moreover, keeping natural resources on earth without using harmful materials is the prime goal of green chemistry. Also, it was found that it is critical to develop substitute technologies that are safer for both human health and the environment. Furthermore, through various methods of green chemistry environment can be preserved. Nearly most of them are biocatalysis, usage of alternate repeatable raw materials (biomass), diverse reaction solvents (such as water, supercritical fluids, ionic liquids) alternative reaction circumstances likewise Electron beam irradiation method, new photocatalytic reactions, microwave irradiation, radiolysis, ultrasound irradiation etc. With the introduction of 12 principles of green chemistry, guidelines were provided by the OECD (Organisation for Economic Cooperation and Development) for chemists to develop clean environment-friendly methodologies that are sustainable for the long term. These principles incorporate: Less hazardous chemical synthesis, atom economy, prevention, designing safer chemicals, design for energy efficiency, safer solvents, reduced derivatives, use of renewable feedstock, catalysis, design for degradation, inherently safer chemistry for accident prevention, and real-time analysis for population prevention.
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    Importance of Pharmacovigilance in Ayurveda
    (Chitkara University Publications, 2021-11-08) Susheel Kumar; Rashmi Arora; Ritchu Babbar; Rajwinder Kaur
    Introduction: Ayurveda has been introduced in India around 1500 BC. Ayurvedic medicines are more accepted these days as people are looking out for the natural medications. The major function of this system is to preserve the normal wellness of people and to cure the patient. These medicines, which are generally considered as safer, are now in the aura of doubt, due to some of the recent incidences of Adverse Drug Reaction (ADR), during their usage. Objective: Pharmacovigilance is an important step in Ayurveda to overcome and continuously monitor the ADR. Pharmacovigilance is the law and regulations for pharma industries, which deal with the detection, assessment, monitoring, understanding, prevention and reporting of adverse effects of medicines. Thus, this is the recurrent theme of ayurvedic pharmacology (dravyagunavigyan) and healing (chikitsa). The most important aim of pharmacovigilance, that is to enhance patient care and safety of the drug use, and as a result elevate rational drug use are recurring premise of ayurvedic pharmacology cology (dravyagunavigyan) and therapeutics (chikitsa). Methods: The data was collected from different websites and databases such as PubMed, Biomedical Sciences, Science Direct, Wiley Online Library, Google Scholar, WHO, Bentham science etc. A total of 80 articles were downloaded, studied, categorized and 52 were selected to write the manuscript. Results and Conclusion: There is requirement of an appropriate post-clinical surveillance program for ayurvedic drugs based on its quality, safety, and efficacy, for public health and disease management, which is now accessible in National Pharmacovigilance Programme for ASU (Ayurveda, Siddha, Unani) drugs, Ayurveda has explained a broad hypothesis on homeopathy medicines, in relation with its usage, causal ADR, treatment and its prevention. Spontaneous reporting of ADR related to Ayurveda plays an essential role in the identification and detection of new signals and communicating novel research questions.