Browsing by Author "Rakesh K Sindhu"

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    Clinical Symptoms and Therapies for Multiple Sclerosis
    (Chitkara University Publications, 2015-05-20) Ashwani Arya; Sahil Kumar; Rakesh K Sindhu
    Multiple Sclerosis (MS) is a chronic form, progressive and immune mediated central nervous system disorder that affects both adults and children. MS is characterized by the development of multiple lesions with the nerve fibers in the spinal cord, optic nerves and brain. Multiple sclerosis affects the approximately 2.5 million people worldwide. A triad of symptoms characterize the disease: fatigue, changes in sensation, ataxia, muscle weakness, dysarthria, dysphagia, visual problems, chronic or acute pain, difficulties of bladder and bowel. The diagnosis of Multiple Sclerosis is made on the foundation of the signs and symptoms, with magnetic resonance imaging and additional laboratory tests playing a helpful role. Every tests are non precise and simply supply supportive indication for diagnosis. A few people have a inadequate number of “relapses” or “attacks” and remain fairly healthy for decades, others may worsen rapidly from the time of analysis, through shortened lifespan and poor excellence of the life. The prognosis is problematical to forecast; it depends on the initial symptom, subtype of the illness, the individual patient’s disorder characteristics. The substantial variability in multiple sclerosis manifestations leads to elevated figure of misdiagnoses each year, but advances in knowledge and pharmaceuticals are leading to more exact identification and successful management. Early diagnosis and management is essential in reducing the severity of disease.
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    Phytoalexins: Sources and Their Pharmacological Potential
    (Chitkara University Publications, 2020-05-20) Rakesh K Sindhu; Bhavika Arora; Sandeep Arora
    Background: Plants are easily prone towards microbial infections on exposure to microorganisms and pathogens. In order to defense, plants produce low molecular weight secondary metabolites which were later known as “Phytoalexins”. These molecules have vast therapeutic potential also. Purpose: The purpose of this review is to explore the phytoalexins and their pharmacological effects. Methods: The data included from the articles were published from Web of Science, PubMed, Medline, Scopus, and Embase by using relevant keywords including plants possessing phytoalexins and their specific biological applications. Results: The review insights the potential of phytoalexins in various diseases and to explore phytoalexins applications in human health and disease control. Conclusions: On the basis of this review it may be concluded that phytoalexins have tremendous potential in the treatment and prevention of various life-threatening diseases like diabetes mellitus, cancer, brain damage, and heart attack.