Browsing by Author "Praveen Kumar"

Now showing 1 - 2 of 2
  • No Thumbnail Available
    Item
    Effectiveness of Clinic-Based Vision Therapy for Non-Strabismic Binocular Vision Anomalies (NSBVA) Among Adults
    (Chitkara University Publications, 2023-10-16) Amit Bhowmick; Praveen Kumar; Jameel Rizwana Hussaindeen
    Background: To assess the effectiveness of clinic-based vision therapy in adults with non-strabismic binocular vision anomalies. Methods: This retrospective study was conducted between January 2018 and December 2021 at a tertiary eye care center in Southern India. Electronic medical records of adults aged 30 years and above diagnosed with non-strabismic binocular vision anomalies, and who underwent a mini-mum of five sessions of clinic-based vision therapy (VT), were reviewed. Clinical parameters of vergence and accommodation were analyzed pre and post-therapy. Results: A total of 44 participants meeting the inclusion criteria were included in the study, with a mean (SD) age of 36 (±6) years. The participants were categorized into two groups based on the completion of either five sessions (Group A) or ten sessions (Group B) of vision therapy (VT). The overall median (IQR) for near phoria was -4 (-8 to 0) PD, the near point of convergence break point was 8 (4 to 12) cm, fusional convergence amplitude for near was 25 (14 to 30) PD, and binocular accommodative facility and amplitude were 3 (0 to 6) cpm and 9 (7 to 10) D, respectively. Conclusion: Clinic-based vision therapy is efficacious in managing non-strabismic binocular vision anomalies in adults.
  • No Thumbnail Available
    Item
    In Silico Evaluation of Reserpine as Potential Anti-Candidal Agent
    (Chitkara University Publications, 2021-05-07) Nidhi Rani; Rajwinder Kaur; Prerna Sharma; Praveen Kumar
    Background: Candida albicans is a fungus that can cause mortality if not treated properly. Lanosterol 14α-demethylase produces Ergosterol, the main sterol in the fungal cell membrane, when the enzyme Lanosterol-demethylase is present (Cytochrome P450DM). This enzyme is a target enzyme for azole antifungal medications. Purpose: In silico evaluation of reserpine as Potential Anti-Candidal agent. Method: The target enzyme was chosen and modelled as part of the project. Molecular docking studies were used to investigate Reserpine’s inhibitory impact on Cytochrome P450. MolegroVirtual Docker was used to conduct molecular docking and Chem sketch was utilised to build compound structures. Result and conclusion: According to the docking research, reserpine exhibited interactions with the demethylase enzyme.