Browsing by Author "Pranav Kumar Prabhakar"

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    Iron and β-Cell Function: Implications for Diabetes Pathophysiology
    (Chitkara University Publications, 2023-04-22) Harpreet Kaur Massaon; Pranav Kumar Prabhakar
    Background: The intricate relationship between iron metabolism and diabetes mellitus has become a subject of increasing interest, with a growing body of evidence suggesting that iron plays a significant role in the pathophysiology of diabetes. Specifically, the impact of iron on β-cell function has emerged as a critical area of study. Β cells, located in the pancreatic islets of Langerhans, are responsible for insulin synthesis and secretion. Purpose: Understanding how iron influences these vital cells is crucial for unraveling the complexities of diabetes development and progression. Methods: This review synthesizes current literature on the interaction between iron and β-cell function, exploring the molecular and cellular mechanisms underlying this relationship. We conducted a systematic search of databases, including PubMed and Scopus, to identify relevant studies published up to the present date. Articles were selected based on their focus on iron homeostasis, β-cell function, and their implications for diabetes pathophysiology. Results: Iron is an essential micronutrient that participates in various cellular pro-cesses, including energy metabolism and reactive oxygen species (ROS) regulation. In β cells, iron is intricately involved in insulin synthesis, folding, and maturation. However, an imbalance in iron homeostasis can lead to oxidative stress, mitochondrial dysfunction, and impaired insulin secretion. The reviewed literature provides compelling evidence that alterations in iron levels can adversely affect β-cell function, contributing to the development and progression of diabetes. Excess iron has been associated with increased oxidative stress within β cells, leading to damage and dysfunction. Furthermore, iron-induced ROS may activate inflammatory pathways, promoting β-cell apoptosis and insulin resistance in peripheral tissues. Conversely, iron deficiency may also impact β-cell health. Insufficient iron availability can compromise the efficiency of insulin synthesis and secretion, potentially contributing to glucose dysregulation. Iron-deficient conditions may lead to alterations in cellular energy metabolism, further exacerbating the vulnerability of β cells to stressors. Conclusions: Understanding the nuanced interplay between iron and β-cell function has implications for diabetes management. Therapeutic strategies aimed at modulating iron levels, such as iron chelation or dietary interventions, hold promise for preserving β-cell health and improving glycemic control. This review underscores the intricate relationship between iron and β-cell function, providing valuable insights into the pathophysiology of diabetes. Whether through excess or deficiency, iron significantly influences the health and function of β cells, shaping the landscape of diabetes development. Further research is warranted to delineate the precise mechanisms involved and to explore targeted interventions that may harness the therapeutic potential of modulating iron levels in diabetes management.
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    Unveiling Therapeutic Prospects: Evaluating the Anti-Arthritic Properties of Thymosin Alpha 1
    (Chitkara University Publications, 2023-10-13) Indu Bala; Pranav Kumar Prabhakar
    Background: Thymosin alpha 1 is a peptide naturally occurring in the thymus that has long been recognized for modifying, enhancing, and restoring immune function. Purpose: The present study focuses on the effects of Thymosin alpha 1 on Body weight, Paw weight, paw volume and arthritic score of Collagen induced arthritis (CIA) rats. Methods: The wistar rats were randomly divided into 5 groups: nor-mal control, arthritic control, CIA+Ta-1 0.25mg/kg, CIA+Ta-1 0.5mg/kg and CIA+Ta-1 mg/kg. The collagen and lipopolysaccharide (LPS) were administered via the intraplantar route to the experimental rat subjects. Prior to the administration of collagen and LPS, the initial paw volume was measured, and the body weight was duly document-ed. The administration of the treatment occurred on the first, third, and fifth days. On the completion of the dosing period, specifically on the fifteenth day, the final body weight was duly recorded. The measurements of paw volume, paw weight, Body weight and arthritic score were duly recorded. Results: Following with the administration of Thymosin alpha-1 the arthritic rats shown significantly reduce the severity of arthritis by decreasing the symptoms of arthritis. Conclusions: Thymosin alpha-1 has shown a promising effect of the reduction in the pathophysiology of rheumatoid arthritis and hence it can be a better therapeutic candidate of future for the management of RA. The more detailed analysis of the mechanistic study may provide a better understanding.