Browsing by Author "Neelima Sharma"

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    Comparative Evaluation of Antioxidant and Anti-Depressant Activity of Macrotyloma Uniflorum vs. Clitoria Ternatea Methanolic Leaf Extracts
    (Chitkara University Publications, 2023-11-10) Amit Kumar; Sayak Khawas; Kumar Anand; Neelima Sharma
    Background: Depression and anxiety are prevalent psychiatric disorders in the modern era, often attributed to the alterations in signalling neurotransmitters or the release of biogenic amines characterized by changes in consciousness, psychomotor functions, and emotional disturbances. Purpose: Several antidepressant drugs are available; they may cause irreversible adverse effects. Therefore, exploring herbal remedies as an alternative therapy holds potential benefits. Macrotyloma uniflorum and Clitoria ternatea are among the plants traditionally utilized for their anti-depression activity. Method: This study aims to compare the antidepressant activity of the methanolic extracts of M. uniflorum and C. ternatea leaves. Their phytochemical compositions were analysed, and antioxidant activities were evaluated using DPPH and Superoxide radical scavenging assays. Results: The outcomes of phytochemical screening indicated the presence of secondary metabolites in both extracts, including alkaloids, saponins, glycosides, steroids, flavonoids, phenols, terpenoids and tannins. The antioxidant assays indicated significant antioxidant potential in both M. uniflorum and C. ternatea extracts. Various biochemical assays, behavioural studies, and histopathological evaluations were conducted using a toluene-induced mice model. Conclusion: The behavioural study and biochemical estimations confirmed the antidepressant potential of both extracts. However, the M. uniflorum extract exhibited better efficacy in alleviating depressive symptoms. In light of future perspectives, it would be valuable to isolate and identify the specific compounds facilitating a more targeted pharmacological approach for depression pharmacotherapy.
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    Harnessing the Power of Natural Products in Drug Discovery
    (Chitkara University Publications, 2023-04-10) Kumar Anand; Sayak Khawas; Apurva Singh; Puja kumari; Neha Nupur; Neelima Sharma
    Background: Natural products and their structural analogues have historically played a crucial role in pharmacotherapy, especially in the treatment of cancer and infectious diseases. However, various challenges including screening, isolation, characterization and effectiveness contributed to a decline in natural product research within the pharmaceutical industry. Purpose: This review explores the enduring use of natural compounds in folk medicine with special focus on drug discovery inspired by multifaceted molecular roles of small molecules from natural sources. The article also aims to elucidate how modern modifications of these compounds can lead to the development of innovative molecules with enhanced pharmacological potential & can have good pharmaceutics profile. Methods: To accomplish these objectives, literature has been surveyed from PUBMED, MEDLINE, EMBASE etc. like search engines, for pinpointing detailed technological developments that empower natural product-based drug discovery. Various case studies are incorporated in terms of folklore usage, in process drug discoveries and small molecules scientifically founded with signalling pathway bio stimulation. Conclusions: The journey of natural products from nature to clinic is very complex and time taking. In this pipeline, if attention can be drawn to some major aspects, it will lead to a paradigm shift in drug discovery processes. This can be witnessed by folklore usage of natural products and up laddering multifaceted concepts of small and lead molecule.
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    Recent Advances in Lipid Nano-Carrier Systems for the Management of Inflammatory Diseases: A Comprehensive Review
    (Chitkara University Publications, 2023-11-10) Kumar Anand; Sayak Khawas; Apurva Singh; Rashmi Kumari; Neelima Sharma
    Background: In the past two decades, extensive research has focused on lipid nanocarriers for targeted drug delivery to treat various diseases. Among these, inflammatory conditions pose a formidable challenge in modern healthcare, encompassing a diverse spectrum from autoimmune disorders to chronic inflammation. Effective therapeutic interventions necessitate the development of targeted and efficient delivery systems to address the complexities associated with drug administration. Purpose: This review highlights different approaches of lipid-based nanocarriers to target various inflammatory diseases, such as rheumatoid arthritis, inflammatory bowel disease (IBD), psoriasis, asthma, and chronic obstructive pulmonary disease (COPD). It focuses on the advancements made in Lipid Nano-Carriers (LNC) with a special emphasis on their inherent safety, lower stability costs, and enhanced encapsulation efficiency. Methods: Recent literature has been surveyed from PUBMED, GOOGLE SCHOLAR, etc., like search engines, for summarising detailed ongoing developments in the field of lipid nanocarriers for inflammatory diseases, which could prove to be a novel carrier for efficient drug delivery with special emphasis on surface modifications, formulations, pharmacokinetics, and efficacy. Conclusion: This review emphasizes recent researches in the field of lipid-based nano formulations for managing inflammatory disease, as well as extensive discussion on their limitations and future prospective.