Browsing by Author "Jaspreet Kaur"

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    Development, physicochemical characterization and in-vitro evaluation of herbal sunscreen lotion
    (Chitkara University Publications, 2015-11-17) Sandeep Arora; Neelam Sharma; Akanksha Mahajan; Jaspreet Kaur; Sukhbir Singh
    Ultraviolet radiations have shorter wavelengths and can reach earth’s surface through penetrating clouds. UV-A rays leads to aging while UV-B rays causes burning of skin. Sunscreens protect the skin from harmful effects of sun including appearance of erythema, premature photo-ageing and facilitate to diminish the manifestation of facial red veins and blotchiness. In this investigation, herbal sunscreen was prepared using Shea butter, almond oil, raspberry oil, jojoba oil, zinc oxide and titanium dioxide as active ingredients. Fabricated lotions were evaluated for physicochemical parameters i.e. color, pH, viscosity and spreadability. Sun protection efficacy of lotion was determined in term of sun protection factor (SPF) by in-vitro spectrophotometric method. Total 10 formulations were made with different compositions F1-F10. The pH of formulations ranges from 6.10 (F6) to 8.34 (F5). The viscosity of formulations ranges from 1500 (F1) to 3586 (F10). The spreadability of formulations ranges from 10.56±0.8 (F1) to 30.65±0.7 (F10). The physicochemical parameters of formulation F6 and F10 were found to be in controlled range justifying its compatibility with skin and confirming good cosmetological property. Stability study of optimized lotion was performed after storage of formulation at 25°C and 60 % RH as well as 40°C and 75 % RH for three months. Stability of lotion was evaluated on the basis of changes in physicochemical parameters i.e. color, pH, viscosity and spreadability and SPF. F10 has SPF value of 15.71±0.07 (medium protection sunscreen). The optimized formulations might provide good moisturizer, emollient, anti-ageing and anti-wrinkle effect with good sun protection.
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    Ellagic Acid Administration Reverses Colchicine- Induced Dementia in Rats
    (Chitkara University Publications, 2016-05-07) Jaspreet Kaur; Manish Kumar; Nitin Bansal
    The late-onset sporadic type of Alzheimer’s disease is characterised by chronic oxidative stress, neuroinflammation and cognitive dysfunction. Ellagic acid is a naturally occurring polyphenol known to possess robust antioxidant property. In the present study, memory enhancing potential of ellagic acid has been explored against ICV colchicine induced dementia in rats. Colchicine (15μg/rat) was administered to Wistar rats (200g) through intracerebroventricular (ICV) route by using stereotaxic apparatus. ICV colchicine induces Alzheimer’s disease like changes in the brain such as rampant free radical production, neuroinflammation and selective neurodegeneration in hippocampus and cortex by acting as an antitubulin agent (mitotic poison). Ellagic acid (17.5 and 35 mg/kg, p.o.) was administered to rats for 25 successive days. Morris water maze and elevated plus maze paradigms were utilized to assess the spatial memory of rats. Oxidative stress biomarkers along with TNF-α were also measured in brain of rats. Ellagic acid prevented the ICV colchicine triggered cognitive deficits as evident by a significant (p<0.05) reduction in mean escape latency during acquisition trial and increased (p<0.05) time spent in target quadrant during probe trial in Morris water maze test, and reduction (p<0.05) in transfer latency in elevated plus maze test. Furthermore, both the doses of ellagic acid attenuated ICV colchicine induced rise in brain TBARS as well as TNF-α and simultaneously enhanced the GSH content.Ellagic acid prevented the brain of rodents from dementing effects of colchicine by attenuating the oxidative damage.