Browsing by Author "Hitesh Chopra"
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Item Pharmacogenomics: Applications in Drug Discovery and Pharmacotherapy(Chitkara University Publications, 2014-05) Hitesh Chopra; Sandeep Kumar; Vandana; Sandeep AroraPharmacogenomics is the scientific study which explains individual variability of drug targets and to explore the genetic basis for such changes. With the completion of human genomic study, clear relation could now be established between the drug response in relation to a person’s genome. Pharmacogenomics, also known as personalized medicine, uses the person’s genome to determine the dose and dosage regimen, so that therapy could be optimized. As with the techniques like DNA microarray technologies person’s response to a therapy can be predicted and new therapies could be assigned. In the present review, the current technologies, and past significance has been discussed.Item Pulsatile Drug Delivery System – A Novel Approach for Time and Spatial Controlled Drug Delivery(Chitkara University Publications, 2016-05-07) Umang; Prashant Sharma; Hitesh Chopra; Sandeep KumarThe area of pharmaceutical research is broadened with the invention of new pharmaceutical drug delivery system. The traditional drug deliveries systems have not the way to treat or cure special disease or as well as the common disease with less side effects and maximized efficacy. ODDS have various advantages and disadvantages but their disadvantages are overcome by the CDDS. CDDS although they overcome the disadvantages of ODDS but do not handle the special pharmacological disease requirements. To overcome this PDDS is established to overcome the disadvantages of CDDS. PDDS has gained importance in the drug delivery system because of improved patient compliance, therapeutic efficacy and having fewer side effects. PDDS uses lag time for delivery of drug in body. Various systems are there in PDDS to overcome the patient’s special chronopharmacological needs.