Browsing by Author "Gaaminepreet Singh"

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    Mechanistic role of herbals as alternative therapy for epilepsy
    (Chitkara University Publications, 2022-05-07) Diksha Sharma; Veerta Sharma; Gaaminepreet Singh; Thakur Gurjeet Singh; Amarjot Kaur Grewal
    Botanicals and herbs have been used by people with epilepsy for ages in various cultures across the world. Patients in both developing and developed nations are currently using herbal remedies to manage seizures or side effects from antiepileptic medicines (AEDs). The deleterious effects of AED medication have a greater impact on the patient’s life than seizures. Alternative remedies should be used to treat and manage epilepsy because synthetic pharmaceuticals have risks. Epilepsy may be managed and treated using herbal medicines that have fewer negative effects than pharmaceutical medications. Therefore, the current review discusses about the herbal drugs used in treatment of epilepsy.
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    Regulatory and Pathological Roles of CaSR and TRPC in Podocytes
    (Chitkara University Publications, 2021-05-07) Ashish; Gaaminepreet Singh; Thakur Gurjeet Singh
    Background: Podocytes, or glomerular visceral epithelial cells, are highly special-ised epithelial cells that cover the glomerular basement membrane’s outer surface. Recent research suggests that podocytes play a signifi-cant role in the physiology and pathology of the glomerulus. The calcium-sensing receptor (CaSR) has a variety of roles in maintaining systemic calcium homeostasis, and it is expressed by a variety of cell types, each with its own set of regulatory activities. CaSR activation in podocytes provides prosurvival effects and protects the cell against puromycin aminonucleoside damage, according to new research by Oh and associates. Purpose: Given that CaSR activation has mostly context-dependent cellular implications, further research is needed to determine its specific involvement in podocyte physiology and pathology. Glomerular kidney disease is a significant healthcare burden, and it is thought to be a collection of illnesses for which there is no precise and effective treatment. Conclusion: Excellent scientific and genetic research have identified processes that go wrong in podocytes, the glomerular filter’s regulating cells. Now the challenge is how to des-ignate targets for new, better medicines.