Browsing by Author "Deepak Kajla"

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    Acupuncture: A Potential Therapy for Neurological and Psychiatric Disorders
    (Chitkara University Publications, 2023-11-10) Deepak Kajla; Maneesh Mohan; Kenneth C. Ugoeze
    Background: Acupuncture, a practice rooted in traditional Chinese medicine for thousands of years, is increasingly recognized as a complementary therapy for neurological and psychiatric disorders. Purpose: This review aims to explore recent advancements in acupuncture’s application for treating specific neurological and psychiatric conditions and to highlight its therapeutic potential and underlying mechanisms. Methods: The review synthesizes findings from extensive research and scientific studies, incorporating insights from modern neuroimaging techniques like functional magnetic resonance imaging (fMRI) and positron emission tomography (PET). It also examines the efficacy of combined modalities, such as laser and electroacupuncture. Results: Acupuncture has demonstrated efficacy in managing neurological conditions such as stroke, neuropathic pain, and neurodegenerative diseases by enhancing cerebral blood flow, promoting neuroplasticity, and providing neuroprotection. Its application in psychiatric disorders, including anxiety, depression, and post-traumatic stress disorder (PTSD), has shown promising outcomes. These therapeutic effects are mediated through mechanisms involving the autonomic nervous system, decreased inflammation, and neurotransmitter regulation. Combining acupuncture with modalities like laser and electroacupuncture has expanded treatment options and enhanced efficacy. Conclusion: Recent advancements underscore acupuncture’s promise as an effective adjuvant therapy for neurological and psychiatric conditions. However, challenges remain in standardizing procedures and refining study designs to better define specific mechanisms and optimize therapeutic parameters. Continued research is essential to establish acupuncture as a reliable treatment option for improving patient outcomes.
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    Anti-diabetic Potential of Traditional Herbal Drugs in Polyherbal Formulation–A Review
    (Chitkara University Publications, 2024-04-20) Suryakant Verma; Milind Sharad Pande; Ravinder Kumar Mehra; Deepak Kajla; Akhil Sharma; Ashi Mannan; Manu Grover; Muhammad Tawhid
    Background: Diabetes mellitus, characterized by hyperglycemic symptoms, has emerged as a major global health challenge. The disease’s severity is compounded by both micro- and macrovascular complications associated with hyperglycemia, leading to significant morbidity. Current conventional anti-diabetic medications, while widely prescribed, often demonstrate high failure rates and are associated with adverse pathological effects. Purpose: This paper aims to evaluate the potential of polyherbal formulations in the treatment of diabetes mellitus, addressing the need for alternative therapeutic approaches with enhanced efficacy and reduced side effects. Methods: The study examines various natural extracts and their constituents derived from medicinal plants, focusing on their hypoglycemic properties. Special attention is given to polyherbal formulations, which combine multiple herbs to potentially enhance therapeutic efficacy while reducing individual herb concentrations and associated adverse effects. Results: While numerous herbal medications have been developed for diabetes mellitus treatment, the review identifies a significant gap in scientific validation and medical proof of their efficacy. Polyherbal formulations show promise in enhancing therapeutic action while minimizing adverse events through reduced concentrations of individual herbs. Conclusion: The investigation highlights the potential of polyherbal formulations as an alternative approach to diabetes management. However, there is a crucial need for rigorous scientific validation and clinical trials to establish their efficacy and safety profiles before widespread implementation in diabetes treatment protocols.
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    Current Status of Multi Drug Resistance- Tuberculosis: A Major Public-Health Threat
    (Chitkara University Publications, 2024-11-20) Deepak Kajla; Veerta Sharma; Ashi Mannan; Tanveer singh; Pankaj Kumar Singh
    Background: Rifampicin is the most effective first-line antibiotic for tuberculosis (TB). However, drug resistance, particularly multidrug-resistant TB (MDR-TB), poses a significant global health challenge. According to the World Health Organization (WHO), approximately 500,000 new TB cases in 2019 were resistant to treatment, with 78% showing multidrug resistance. India alone accounted for 27% of all MDR or rifampicin-resistant (RR) TB cases reported in 2020. MDR-TB, defined by resistance to at least isoniazid and rifampicin, is primarily driven by poor adherence to treatment, inappropriate antibiotic use, and transmission in crowded settings. Purpose: This review highlights the increasing threat of MDR-TB and underscores the need for alternative therapeutic strategies, improved diagnostic tools, and updated treatment guidelines to combat drug-resistant TB effectively. Methods: A literature-based analysis was conducted, focusing on recent WHO reports, updated guidelines, and emerging approaches in MDR-TB diagnosis and management, including molecular diagnostics, novel oral drugs, and adjunctive therapies such as nutritional and traditional support systems. Results: Recent WHO guidelines emphasize early detection using advanced molecular techniques and the use of repurposed oral anti-TB medications. These strategies show promise in enhancing disease control and patient outcomes. However, the implementation of new regimens requires further clinical evaluation. Integration of supportive care approaches such as nutrition and traditional therapies may contribute to a more holistic management of MDR-TB. Conclusion: The growing prevalence of MDR-TB and XDR-TB calls for urgent action in diagnosis, treatment, and patient support. While revised WHO strategies offer a promising framework, continued research and clinical trials are vital to optimize therapies and address global TB drug resistance effectively.