Browsing by Author "Atul A. Shirkhedkar"

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    An Insight on Analytical Profile on Bisoprolol Fumarate – A Selective Beta-1 Adrenoreceptor Blocker
    (Chitkara University Publications, 2017-11-02) Ajinkya G. Dhandar; Suraj R. Chaudhari; Saurabh B. Ganorkar; Amod S. Patil; Sanjay J. Surana; Atul A. Shirkhedkar
    BF is Beta-adreno receptor antagonist and used as an AntiHypertensive Drug. BF gives the blocking action on β1-adrenergic receptors in the heart and vascular smooth muscle. The present review compiles the various approaches implemented for quantification of BF in bulk drug, pharmaceutical matrix and biological fluid. This review represents more than 50 analytical methods which include capillary electrophoresis, HPLC, HPTLC, UV-Spectroscopy, UPLC, impurity profiling and electrochemical methods implemented for estimation of BF as a single component as well as in multicomponent.
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    Analytical Review on Raloxifene -An Estrogen Receptor Modulator in Different Pharmaceutical Formulations and Biological Fluids
    (Chitkara University Publications, 2017-05-05) Ashwini v. Gujar; Anand B. Mundada; Atul A. Shirkhedkar
    Raloxifene (RLX) is an oral selective estrogen receptor modulator (SERM). It is showing estrogenic action on bone and anti-estrogenic action on uterus and breast. An extensive literature has been published for analysis of RLX in different pharmaceutical formulations. This review article endeavor to provide the detail account on analytical methods for RLX and also validation details for its readers. It further helps to avoid costly chemicals and time consuming exercises for further investigation of RLX.
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    Development and Validation of UV Spectrophotometric Method for Simultaneous Estimation of Quinfamide and Mebendazole in in-house Pharmaceutical Formulation
    (Chitkara University Publications, 2018-05-02) Ajinkya G. Dhandar; Saurabh B. Ganorkar; Amod S. Patil; Atul A. Shirkhedkar
    The present work described the development of two simple, accurate, rapid, cost effective and reproducible UV-Spectrophotometric methods for the simultaneous estimation of Quinfamide and Mebendazole in bulk and in laboratory mixture using 0.01M methanolic HCl as a solvent. The absorption maximum for Quinfamide and Mebendazole were found to be at 260.00 nm and 232.40 nm respectively. Beer’s – lamberts was followed in concentration ranges of 1 – 6 μg/mL for Quinfamide and 2- 12 μg/mL for Mebendazole. The percentage recovery of Quinfamide and mebendazole ranged from 98.48 to 99.08 and 98.83 to 99.62 (Method I); from 98.14 to 98.93 and 99.16 to 99.35 (Method II) for Quinfamide and Mebendazole. The established methods were sensible for simultaneous quantitative determination of both these drugs in fixed dose combinations. Validation of both these methods was performed as per ICH guidelines. The developed methods can routinely be used for estimation of both these drugs in their combined dosage form.
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    Estimation of Delafloxacin Using Derivative Spectrophotometry and Area Under Curve in Bulk Material and in Laboratory Mixture
    (Chitkara University Publications, 2016-05-07) Kiran R. Dhangar; Atul A. Shirkhedkar
    Simple, specific, rapid and accurate UV-spectrophotometric methods have been developed using a solvent acetonitrile (50 %) to determine delafloxacin in bulk material and in laboratory mixture. “Method A” is zero order derivative UV- spectrophotometry using absorbance, “Method B” is zero order derivative UV-spectrophotometry using Area Under Curve (AUC) technique, “Method C” is first order derivative UV-spectrophotometry using amplitude, “Method D” is First Order Derivative UV-spectrophotometry- AUC,“Method E” is Second Order Derivative UV-spectrophotometry using amplitude and “Method F” is second order derivative UV- spectrophotometry using (AUC) technique. The developed methods have shown excellent results in terms of linearity and range, accuracy, precision and Limit of Detection (LOD) and Limit of Quantification (LOQ). In all Methods, delafloxacin obeyed linearity in the concentration range of 2 – 12 μg/mL with (r2 > 0.999). All these methods were applied for estimation of delafloxacin in laboratory mixture. All the above mentioned methods were validated considering linearity and range, accuracy, precision, ruggedness and sensitivity.
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    Pharmaceutical Analysis of Eptifibatide via Simple, Rapid, Economical UV-Spectrophotometric Methods
    (Chitkara University Publications, 2015-05-20) Sushant S. Patil; Saurabh B. Ganorkar; Atul A. Shirkhedkar
    Eptifibatide is an antiplatelet drug of the glycoprotein IIb/IIIa inhibitor class. Pharmaceutically it is applied to reduce the risk of acute cardiac ischemic events. The present work reveals two simple, rapid and economical UuV-Spectrophotometric methods for pharmaceutical analysis of Eeptifibatide bulk and in parenteral formulation. The ‘Method I’ is based on the Zero Order Spectrophotometric determination of drug at its wavelength maximum 218.20 nm and ‘Method II’ employed First Order Derivative – Aarea Uunder Curve (AUauC) technique in which the area has been integrated between two wavelengths 220.20 to 237.20 nm. The drug obeyed linearity in the concentration range of 3 – 18 μg/mLl with coefficient of correlation; greater than 0.999 in both methods. The amounts of drug determined by both methods are in conformity with label claim. These methods are validated for accuracy, precision and ruggedness with % RSD value less than 2.0.
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    UV-Spectrophotometry – Multicomponent Mode of Analysis for Simultaneous Estimation of Brinzolamide and Brimonidine Tartrate in Bulk and Ophthalmic Formulation
    (Chitkara University Publications, 2019-05-10) Vikram L. Jadhav; Amod S. Patil; Suraj R. Chaudhari; Atul A. Shirkhedkar
    Brinzolamide (BRZ) and Brimonidine Tartrate (BT) in combination are available as an ophthalmic suspension in the ratio of 5:1. A simple, reproducible and efficient method for the simultaneous determination of BRZ and BT in Bulk and Ophthalmic formulation has been developed. The absorbance was assessed at two wavelengths i.e. 252.40 nm (λ max of BRZ) and 246 nm (λmax of BT) in methanol. In this method, BRZ and BT executed linearity in the concentration range of 5-35 μg/mL and 3-18 μg/mL, respectively at their respective λ max. The developed method was found to be accurate, precise and rugged as marked by small values of % RSD according to ICH guidelines.