Browsing by Author "Amit Kumar"

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    Antioxidant Potential of Glycyrrhiza glabra L. roots: In-Vitro Evidences
    (Chitkara University Publications, 2020-05-20) Varinder Singh; Amit Kumar
    Background: The study was aimed to determine the mechanism of antioxidant effects of Glycyrrhiza glabra L. (GG) roots using in-vitro assays. Methods: The various extracts of GG roots were prepared and evaluated for DPPH scavenging, reducing effects and nitric oxide inhibiting activities. Prepared extracts were screened for the presence of various phytochemicals and quantified on the basis of phytochemical present therein. Results: The results showed that all the prepared extracts contained phenolic compounds. Also, extract showed appreciable antioxidant effects in all three assays employed. However, among prepared extracts, ethylacetate extract was found to have strong free radical inhibition, ferric reducing potential and nitric oxide inhibitory effects. The reason for high antioxidant activity in ethylacetate extract could be attributed to the significant amount of phenol compounds present in it. Conclusion: Evidently, GG’s capacity to scavenge free radicals, reducing potential and inhibit nitric oxide contributes to its antioxidant effects and thus, could be a strong candidate for developing antioxidant based drug therapy.
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    Comparative Evaluation of Antioxidant and Anti-Depressant Activity of Macrotyloma Uniflorum vs. Clitoria Ternatea Methanolic Leaf Extracts
    (Chitkara University Publications, 2023-11-10) Amit Kumar; Sayak Khawas; Kumar Anand; Neelima Sharma
    Background: Depression and anxiety are prevalent psychiatric disorders in the modern era, often attributed to the alterations in signalling neurotransmitters or the release of biogenic amines characterized by changes in consciousness, psychomotor functions, and emotional disturbances. Purpose: Several antidepressant drugs are available; they may cause irreversible adverse effects. Therefore, exploring herbal remedies as an alternative therapy holds potential benefits. Macrotyloma uniflorum and Clitoria ternatea are among the plants traditionally utilized for their anti-depression activity. Method: This study aims to compare the antidepressant activity of the methanolic extracts of M. uniflorum and C. ternatea leaves. Their phytochemical compositions were analysed, and antioxidant activities were evaluated using DPPH and Superoxide radical scavenging assays. Results: The outcomes of phytochemical screening indicated the presence of secondary metabolites in both extracts, including alkaloids, saponins, glycosides, steroids, flavonoids, phenols, terpenoids and tannins. The antioxidant assays indicated significant antioxidant potential in both M. uniflorum and C. ternatea extracts. Various biochemical assays, behavioural studies, and histopathological evaluations were conducted using a toluene-induced mice model. Conclusion: The behavioural study and biochemical estimations confirmed the antidepressant potential of both extracts. However, the M. uniflorum extract exhibited better efficacy in alleviating depressive symptoms. In light of future perspectives, it would be valuable to isolate and identify the specific compounds facilitating a more targeted pharmacological approach for depression pharmacotherapy.
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    Emerging Pathological Events in Liver Diseases of Pregnancy
    (Chitkara University Publications, 2022-11-10) Rajalaxmi Behera; Amit Kumar; Samrat Chauhan; Amarjot Kaur Grewal; Thakur Gurjeet Singh
    Hepatic dysfunction in a gestational woman can arises from pregnancy-related factors, illnesses that occur concurrently with gestation, or previously existing hepatic disorders which is aggravated by pregnancy. Abnormal liver test findings occur in 3% to 5% of pregnancies due to a variety of probable causes, with clinical effects ranging from self-limiting to swiftly deadly. Abnormal liver tests in pregnant individuals are caused by four major conditions: (i) Physiological changes in pregnancy, (ii) Newly acquired Liver disease, (iii) Pre-existing Liver disease, and (iv) Pregnancy-related Liver disease. Physiologic changes in pregnant women lead to abnormal liver function tests. Hepatic disorders may result in severe illness and death in both mothers as well as fetuses. Quick identification of the disease is crucial, as in critical situations immediate delivery is vital for the mother and developing infant survival. This review focuses on liver problems that are specific to pregnancy. Hyperemesis gravidarum (HG), which appears within the first 12 weeks of pregnancy, is connected to liver damage. Intrahepatic Cholestasis of Pregnancy (ICP) is the most prominent all across the middle and the end term of pregnancy. After birth, pruritus and the related biochemical indications of cholestasis resolve. Both pre-eclampsia and HELLP (elevated liver enzymes, hemolysis, and low platelets) are severe conditions that arise in the last term of pregnancy. Acute fatty liver during pregnancy (AFLP) is a potentially dangerous, uncommon condition that can affect pregnancy’s third trimester. This review summarizes the etiologies, pathogenesis, identification, and treatment of hepatic disorders during pregnancy.