Browsing by Author "Amarjot Kaur"

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    Chemical Induced Rodent Model of Autism Spectrum Disorders
    (Chitkara University Publications, 2022-11-10) Kavita Chauhan; Veerta Sharma; Heena Khan; Amarjot Kaur; Thakur Gurjeet Singh
    The term Autism spectrum disorder (ASD) refers to a neuro-developmental disorder that include repetitive behaviours, extremely constrained interests and deficits in social communication. In the last ten years, the numerous epidemiological papers discussing connection between autism and environmental chemical exposures has significantly increased. These findings are crucial because they focus on modifiable risk factors that may open up new possibilities for the primary prevention of the autism-related disability, which is now recognised to be more strongly related to environmental factors than was previously thought. A variety of environmental factors have been known as significant factors relevant to aetiology of ASD, such as lead and mercury (heavy metals), PCB(organic contaminant) and phthalates and BPA. The most accurate animal model of autism among all other models is valproic acid-induced autism, which can reproduce almost all of the molecular and cellular changes seen in humans with ASD. This review provide insight into various diagnostic available for autism, pathophysiology of autism and animal model of autism to develop a pharmacological therapeutic intervention for the treatment of disease.
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    Ebola Hemorrhagic Fever: Recent Update On Disease Status, Current Therapies And Advances In Treatment
    (Chitkara University Publications, 2017-11-02) Jaskaran Singh; Thapa Komal; Sandeep Arora; Amarjot Kaur; Thakur Gurjeet Singh
    Swiftly growing viruses are a major intimidation to human health. Such viruses are extremely pathogenic like Ebola virus, influenza virus, HIV virus, Zika virus etc . Ebola virus, a type of Filovirus, is an extremely infectious, single-stranded ribonucleic acid virus that infects both humans and apes, prompting acute fever with hemorrhagic syndrome. The high infectivity, severity and mortality of Ebola has plagued the world for the past fifty years with its first outbreak in 1976 in Marburg, Germany, and Frankfurt along with Belgrade and Serbia. The world has perceived about 28,000 cases and over 11,000 losses. The high lethality of Ebola makes it a candidate for use in bioterrorism thereby arising more concern. New guidelines have been framed for providing best possible care to the patients suffering from Ebola virus i.e Grading of Recommendation Assessment, Development And Evaluation (GRADE) methodology to develop evidence-based strategy for the treatment in future outbreak of Ebola virus. No drugs have been approved, while many potent drugs like rVSV-EBOV, Favipiravir, ZMapp are on clinical test for human safety. In this review we will discover and discuss perspective aspects that lead to the evolution of different Ebola variants as well as advances in various drugs and vaccines for treatment of the disease.
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    Phytoconstituents in Breast Cancer Prevention
    (Chitkara University Publications, 2022-05-07) Shreya Sood; Sushma Devi; Thakur Gurjeet Singh; Amarjot Kaur; Vinita Singh; Prinsi Sahpuriya
    Background: In today’s developing nations, breast cancer (BC) is among the foremost risk factor for women. The causes of mortality are still unclear, yet they are frequently related to socioeconomic level and way of life. Numerous clinical therapies have been employed up to this point, i.e.,radiotherapy, hormonal treatment, targeted treatment,mastectomy, and treatment with drugs etc. Purpose: However, resistance development to chemotherapeutic drugs, radiation and hormonal therapy is one of the common problems for many of the patients with BC.Numerous studies have looked at the anti-cancer potential of natural products due to the fact that they are generally safe.Researchers’ interest is being drawn by phytochemicals from plants that are thought to be bioactive. In this review the formation and progression of breast cancer were also studied, along with the mode’s of activity and regulatory function of these phytoconstituents in major signalling networks within the cell. Conclusion:Phytoconstituents in Breast Cancer Prevention have potential future as well as the difficulties. So, need more study and instructions for experimental animals, medical research, and experimental in vitro and in vivo methods are critically evaluated.