JPTRM Vol. 4 No. 1 (May 2016)

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https://demodspace.chitkara.edu.in/handle/123456789/131

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Browsing JPTRM Vol. 4 No. 1 (May 2016) by Author "Pratima Sharma"

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    An Update on Some Recent Solubility Enhancers as Pharmaceutical Excipients
    (Chitkara University Publications, 2016-05-07) Vivek Puri; Pratima Sharma; Manju Nagpal
    At present the pharmaceutical academia and industries are focusing on the use of natural materials and resources for development of pharmaceutical product. Due to advances in drug delivery technology, currently, excipients are included in novel dosage forms to fulfill specific functions. Various natural polymers are widely being studied as a potential carrier material for site specific drug delivery because of its non-toxic and biocompatible in nature. Natural polymers (polysaccharides) have been investigated for drug delivery applications as well as in biomedical fields. Modified polymer or synthetic polymers have found its application as a support material for cell culture, tissue engineering and gene delivery. Recent trends towards use of natural products or plant based products demand the replacement of synthetic additives with natural ones. These natural materials have many advantages over synthetic ones as they are biodegradable, chemically inert, less expensive, nontoxic and widely available. This review provides an overview of the different modified polymer derivatives and their applications with special consideration being put on biomedical engineering and controlled drug delivery.
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    Dissolution Enhancement of Domperidone Fast Disintegrating Tablet Using Modified Locust Bean Gum by Solid Dispersion Technique
    (Chitkara University Publications, 2016-05-07) Manju Nagpal; Loveleen Kaur; Janita Chander; Pratima Sharma
    Enhancement of dissolution characteristics of poorly soluble drug Domperidone by solid dispersion technique using modified locust bean gum (MLBG) and further conversion into tablet dosage form with fast dissolving characteristics is being explored in current study. Solid dispersions (SD) were prepared by solvent evaporation technique. F1, F3, F5 and F7 batches of SD (1:1, 1:3, 1:5 and 1:7 ratio of drug to MLBG) were prepared. Maximum solubility was observed in 1:3 ratio (F3 batch) in comparison to pure drug. Fourier Transform Infrared spectroscopy studies revealed no interaction of drug to polymer MLBG. Transition from crystalline to amorphous state of drug was analyzed by X-RD studies. SEM studies revealed change in surface characteristics of drug in solid dispersions. In vitro release studies revealed maximum dissolution in F3 (93% in 30 min). Further solid dispersion batches F3 was compressed into tablets including other excipients and crosspovidone as superdisintegrant. The in vitro release from tablet batch revealed better dissolution characteristics (95% in 30 min) in comparison to marketed tablet (50% in 60 min). Therefore, MLBG solid dispersion tablets of domperidone can be a convenient dosage form with enhanced dissolution characteristics.